Mortality from diseases of the circulatory system in radiologic technologists in the United States
Mortality from diseases of the circulatory system in radiologic technologists in the United States
复制标题
DOI：
10.1093/aje/kwf189
复制
发表时间：
2003-02-01
影响因子：
5
通讯作者：
Mabuchi, K
中科院分区：
文献类型：
--
作者：
Hauptmann, M;Mohan, AK;Mabuchi, K
虽然在接受放射治疗的病人中观察到循环系统疾病的死亡率增加，但长期低剂量辐射照射的影响尚不清楚。在1983-1989年期间回答邮寄问卷的90，284名美国放射技术人员中，作者评估了1997年循环系统疾病的死亡率，并将其与工作历史和工作程序作为辐射暴露的替代品。他们使用Poisson回归模型对性别、种族、年龄和日历年进行分层，并对吸烟、体重指数、酒精摄入、婚姻状况、产次、绝经状态和心肌梗死史进行调整。累计1，107，100人年，1，070例受试者死于循环系统疾病。与1960年及以后相比，1950-1959年、1940-1949年或1940年之前首次就业的相对风险为1.01（95%置信区间（CI）：0.78，1.30）、1.14（95% CI：0.86，1.50）和1.42（95% CI：1.04，1.94）（趋势p < 0.001）。对于脑血管疾病死亡的亚组（n = 174），其相对危险度为0.90（95% CI：0.45，1.78），1.54（95% CI：0.74，3.23）和2.40（95% CI：1.09，5.31）（趋势p = 0.004），缺血性心脏病死亡（n = 633）的相对危险度为0.98（95% CI：0.71，1.35）、1.00（95% CI：0.71，1.42）和1.22（95% CI：0.81，1.82）（趋势p = 0.026）。循环系统疾病和脑血管疾病的死亡率的相对风险随着1950年以前工作年限的增加而显著增加（趋势分别为p = 0.007和< 0.001）。数据表明，1950年以前由于职业性辐射照射而导致的循环系统疾病死亡率增加，当时辐射剂量可能很高。
Although increased mortality from diseases of the circulatory system has been observed in patients treated with radiotherapy, the effects of chronic low-dose radiation exposure are not clear. Among 90,284 US radiologic technologists who responded to a mailed questionnaire during 1983-1989, the authors evaluated mortality from circulatory system diseases through 1997 in relation to job history and work procedures as surrogates for radiation exposure. They used Poisson regression models stratified for sex, race, age, and calendar year and adjusted for smoking, body mass index, alcohol intake, marital status, parity, menopausal status, and history of myocardial infarction. A total of 1,107,100 person-years accrued, and 1,070 subjects died from circulatory system diseases. Relative risks for first employment during 1950-1959, 1940-1949, or before 1940, compared with 1960 and later, were 1.01 (95% confidence interval (CI): 0.78, 1.30), 1.14 (95% CI: 0.86, 1.50), and 1.42 (95% CI: 1.04, 1.94), respectively (trend p < 0.001). For the subset of deaths from cerebrovascular disease (n = 174), the respective relative risks were 0.90 (95% CI: 0.45, 1.78), 1.54 (95% CI: 0.74, 3.23), and 2.40 (95% CI: 1.09, 5.31) (trend p = 0.004), and for deaths from ischemic heart disease (n = 633), the relative risks were 0.98 (95% CI: 0.71, 1.35), 1.00 (95% CI: 0.71, 1.42), and 1.22 (95% CI: 0.81, 1.82) (trend p = 0.026). The relative risks for mortality from circulatory system diseases and the subset of cerebrovascular disease increased significantly with the number of years worked before 1950 (trend p = 0.007 and < 0.001, respectively). The data suggest increased mortality from diseases of the circulatory system with occupational radiation exposure before 1950 when radiation doses were likely high.