Remodeling of reciprocal synapses associated with persistence of long-term memory
Remodeling of reciprocal synapses associated with persistence of long-term memory
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DOI：
10.1111/j.1460-9568.2004.03271.x
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发表时间：
2004-03-01
影响因子：
3.4
通讯作者：
Ichikawa, M
中科院分区：
文献类型：
--
作者：
Matsuoka, M;Kaba, H;Ichikawa, M
我们研究了一种长期记忆模型，其中雌性小鼠在交配时建立其伴侣的信息素记忆。我们研究了副嗅球的相互突触，发现信息素记忆与记忆获得早期兴奋性突触的形态学变化和记忆持续后期抑制性突触的变化有关。在信息素记忆消失后，这些形态学变化不再存在。这些结果表明，持久性的信息素记忆与连续和动态变化的形态可塑性的相互突触的副嗅球。
We investigated a model of long-term memory in which the female mouse establishes pheromonal memory of its partner at mating. We examined the reciprocal synapses of the accessory olfactory bulb and found that pheromonal memory was associated with morphological changes in excitatory synapses in the early phase of memory acquisition and by changes in inhibitory synapses in the late phases of memory persistence. After extinction of pheromonal memory, these morphological changes were no longer present. These findings suggest that the persistence of pheromonal memory is associated with continuous and dynamic changes in the morphological plasticity of reciprocal synapses in the accessory olfactory bulb.