Cannabis use in the last year in a US national sample of twin and sibling pairs.
Cannabis use in the last year in a US national sample of twin and sibling pairs.
复制标题
去年美国全国双胞胎和兄弟姐妹样本中大麻的使用情况。
DOI：
10.1017/s0033291701004950
复制
发表时间：
2002
影响因子：
6.9
通讯作者：
Kessler,RC
中科院分区：
文献类型：
--
作者：
Kendler,KS;Neale,MC;Thornton,LM;Aggen,SH;Gilman,SE;Kessler,RC
背景先前的三项基于人群的双胞胎研究，没有一项具有全国代表性，表明遗传和家庭环境因素都有助于终生吸食大麻的家庭相似性。我们试图将这些结果复制到美国全国双胞胎和兄弟姐妹对的概率样本中，这些样本只检查去年的大麻使用情况。方法去年的大麻使用情况通过自我报告问卷进行评估。结果去年吸食大麻的双胞胎和兄弟姐妹的相似度很高，单卵对的双胞胎和兄弟姐妹的相似程度比异卵和兄弟姐妹的高得多。建模表明，兄弟姐妹的相似是由于遗传因素造成的--遗传力至少为60%--可能还有家庭环境因素。没有证据表明大麻的使用受到特殊的孪生环境的影响。结论与先前的研究一致，大麻的使用在很大程度上受到遗传因素的影响，但家庭环境也可能是重要的。
BackgroundThree prior population-based twin studies, none of which was nationally representative, suggested that both genetic and familial–environmental factors contribute to family resemblance for lifetime cannabis use. We seek to replicate these results in a US national probability sample of twin and sibling pairs examining only last year cannabis use.MethodsCannabis use in the last year was assessed by self-report questionnaire. Biometrical twin analyses were performed.ResultsTwin and sibling resemblance for last-year cannabis use was substantial, and much higher in monozygotic pairs than in dizygotic and sibling pairs, where levels of resemblance were similar. Modeling suggested that sibling resemblance was due to genetic factors – with a heritability of at least 60% – and probably family environmental factors. No evidence was found that cannabis use was influenced by a special twin environment.ConclusionsConsistent with prior studies, use of cannabis is substantially influenced by genetic factors but family–environment is also possibly of importance.