Recycling probability and dynamical properties of germinal center reactions
Recycling probability and dynamical properties of germinal center reactions
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DOI：
10.1006/jtbi.2001.2297
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发表时间：
2001-06-07
影响因子：
2
通讯作者：
Or-Guil, M
中科院分区：
文献类型：
--
作者：
Meyer-Hermann, M;Deutsch, A;Or-Guil, M
我们介绍了生发中心中成中心细胞和成中心细胞动力学的新模型。该模型减少了生发中心对必需元素的反应，并嵌入了成中心细胞的增殖、相应抗体类型在形状空间中表示的点突变、向中心细胞的分化、对初始抗原的选择、正向选择的中心细胞向浆细胞或记忆细胞的分化以及向成中心细胞的再循环。我们只使用具有直接生物学解释的参数，这样，一旦由实验数据确定，模型就获得了预测能力。根据Han等人（1995b）的实验，我们预测，要使生发中心反应可靠地工作，必须有较高的中心细胞再循环率。此外，我们发现相对于点突变的开始，等离子体和记忆细胞的生产开始延迟，这被证明是生发中心反应优化过程中必要的。分析了生发中心反应对回收概率的依赖关系。(C) 2001学术出版社。
We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the corresponding antibody types represented in a shape space, differentiation to centrocytes, selection with respect to initial antigens, differentiation of positively selected centrocytes to plasma or memory cells and recycling of centrocytes to centroblasts. We use exclusively parameters with a direct biological interpretation such that, once determined by experimental data, the model gains predictive power. Based on the experiment of Han ct al. (1995b) we predict that a high rate of recycling of centrocytes to centroblasts is necessary for the germinal center reaction to work reliably. Furthermore, we find a delayed start of the production of plasma and memory cells with respect to the start of point mutations, which turns out to be necessary fbr the optimization process during the germinal center reaction. The dependence of the germinal center reaction on the recycling probability is analysed. (C) 2001 Academic Press.