DNA pooling as a tool for large-scale association studies in complex traits
DNA pooling as a tool for large-scale association studies in complex traits
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DOI：
10.1080/07853890310021724
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发表时间：
2004-01-01
影响因子：
4.4
通讯作者：
Owen, MJ
中科院分区：
文献类型：
--
作者：
Norton, N;Williams, NM;Owen, MJ
混合基因分型是一种强大而有效的工具，可用于病例对照和基于家庭的高通量关联分析。使用汇集设计可以显著降低研究的消耗品和劳动力成本。同时，由于它对DNA资源也非常有效，因此池化可以成为保存DNA的一种非常有效的方法。在这里，我们考虑了研究设计的要点，并以精神病学表型为例说明了池的应用。
Pooled genotyping is a powerful and efficient tool for high throughput association analysis, both case-control and family-based. The use of pooling designs can significantly reduce the consumable and labour costs of a study. At the same time, since it is also extremely efficient with DNA resources, pooling can be an extremely effective method for conserving DNA. Here, we consider the main points in study design, and illustrate the application of pooling using psychiatric phenotypes as an example.