New methods devised specify the size and color of the spots monkeys see when striate cortex (area V1) is electrically stimulated.
New methods devised specify the size and color of the spots monkeys see when striate cortex (area V1) is electrically stimulated.
复制标题
设计的新方法指定了当纹状皮层（V1 区）受到电刺激时猴子看到的斑点的大小和颜色。
DOI：
10.1073/pnas.1108337108
复制
发表时间：
2011
影响因子：
11.1
通讯作者：
Tehovnik,EdwardJ
中科院分区：
文献类型：
--
作者：
Schiller,PeterH;Slocum,WarrenM;Kwak,MichelleC;Kendall,GeoffreyL;Tehovnik,EdwardJ
为盲人创造一种假肢装置是未来的一项中心任务。我们的研究探讨了基于初级视觉皮层（V1区）的电刺激生产假体设备的可行性，该区域在因眼睛损伤而导致视力丧失后多年保持完整。作为这一努力的第一步，我们认为应该在动物身上进行研究，就像在创造非常成功的人工耳蜗植入物一样。我们选择了视觉系统与人类相似的恒河猴，训练猴子完成两项任务，以评估通过微电极刺激V1区的单个部位时产生的知觉的大小、对比度和颜色。在这里，我们报告说，在中央5°的视野表示的电刺激创建一个小斑点，是9和26弧之间的直径，并具有2.6%和10%之间的对比度范围。在大多数情况下，刺激产生的点比动物观察到的背景暗，由各种低对比度颜色组成。这些发现可以用作输入到V1区的电刺激模型。在这些发现的基础上，我们得出什么样的图像将是预期的植入电极阵列时，通过连接到头部的图像被转换成电刺激使用适当的算法的相机进行刺激。
Creating a prosthetic device for the blind is a central future task. Our research examines the feasibility of producing a prosthetic device based on electrical stimulation of primary visual cortex (area V1), an area that remains intact for many years after loss of vision attributable to damage to the eyes. As an initial step in this effort, we believe that the research should be carried out in animals, as it has been in the creation of the highly successful cochlear implant. We chose the rhesus monkey, whose visual system is similar to that of man. We trained monkeys on two tasks to assess the size, contrast, and color of the percepts created when single sites in area V1 are stimulated through microelectrodes. Here, we report that electrical stimulation within the central 5° of the visual field representation creates a small spot that is between 9 and 26 min of arc in diameter and has a contrast ranging between 2.6% and 10%. The dot generated by the stimulation in the majority of cases was darker than the background viewed by the animal and was composed of a variety of low-contrast colors. These findings can be used as inputs to models of electrical stimulation in area V1. On the basis of these findings, we derive what kinds of images would be expected when implanted arrays of electrodes are stimulated through a camera attached to the head whose images are converted into electrical stimulation using appropriate algorithms.