Ultrastructure of telocytes, a new type of interstitial cells in the myocardium of the Chinese giant salamander (Andrias davidianus)
Ultrastructure of telocytes, a new type of interstitial cells in the myocardium of the Chinese giant salamander (Andrias davidianus)
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大鲵心肌中一种新型间质细胞特细胞的超微结构
DOI：
10.4081/ejh.2019.3021
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发表时间：
2019-01-01
影响因子：
2
通讯作者：
Zhang, Hui
中科院分区：
文献类型：
--
作者：
Ge, Tingting;Ye, Yaqiong;Zhang, Hui
端粒细胞(TCs)是一种新的间质细胞，参与组织再生，尤其是心脏组织的再生。因此，TCs有望成为再生医学中很有前途的细胞。然而，关于TCS的区位结构特征和功能的信息还很有限。本研究用透射电子显微镜鉴定了中国大蜥蜴(Andrias Davidianus)心脏的TC。TC位于心肌细胞(CM)间质中。TCs具有明显的超微结构特征，包括1-2个极细长的念珠状端粒、胞体突起、小窝、二分分支、迷路系统、相邻的外体以及TPS之间的同源细胞接触。TCS/TPS多见于心肌细胞附近。此外，TPS还与心肌细胞建立了异种细胞联系。我们的结果证实了田鼠心肌中存在天花粉蛋白。这将有助于我们更好地了解TCS在两栖动物心脏中的作用。
Telocytes (TCs) are new interstitial cells, and they are involved in tissue regeneration, particularly in heart. Therefore, TCs are suggested to be promising cells in regenerative medicine. However, the information of location structural characteristics and functions of TCs is still limited. In this study, cardiac TCs of the Chinese giant salamanders (Andrias davidianus) were identified by transmission electron microscopy. TCs were located in the interstitium between cardiomyocytes (CM). TCs possessed distinctive ultrastructural characteristics, including one to two very long and thin moniliform telopodes (Tps), emerging points from the cell body, caveolae, dichotomous branchings, labyrinthic systems, neighbouring exosomes and homocellular contacts between Tps. TCs/Tps were frequently observed in close proximity to cardiomyocytes. Moreover, Tps established hetero-cellular contacts with cardiomyocytes. Our results confirm the presence of TCs in the myocardium of the A. davidianus. This will help us to better understand roles of TCs in amphibian hearts.