Increased levels of interleukin-1beta and soluble intercellular adhesion molecule-1 in cerebrospinal fluid of patients with subacute sclerosing panencephalitis.
Increased levels of interleukin-1beta and soluble intercellular adhesion molecule-1 in cerebrospinal fluid of patients with subacute sclerosing panencephalitis.
复制标题
亚急性硬化性全脑炎患者脑脊液中白介素-1β和可溶性细胞间粘附分子-1水平升高。
DOI：
10.1093/infdis/175.3.689
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
H. Wiśniewski
中科院分区：
文献类型：
--
作者：
P. Mehta;J. Kulczycki;S. Mehta;P. Coyle;H. Wiśniewski
采用ELISA法检测了亚急性硬化性全脑炎（SSPE）、多发性硬化（MS）或其他神经系统疾病（OND）患者的成对脑脊液（CSF）和血清样本中的促炎细胞因子（白细胞介素[IL]-1 β、肿瘤坏死因子[TNF]-α和IL-6）和可溶性细胞间粘附分子-1（sICAM-1）。与MS或OND组相比，SSPE组CSF中IL-1 β水平显著升高。SSPE组IL-1 β CSF/血清比值高于MS或OND组。TNF-α和IL-6水平在3组中相似。SSPE组脑脊液sICAM-1水平高于MS组和OND组。SSPE组sICAM-1 CSF/血清比值高于OND组。SSPE中IL-1 β和sICAM-1的CSF/血清比值增加，表明中枢神经系统中IL-1 β和sICAM-1的合成，并可能在疾病的发病机制中起重要作用。
Proinflammatory cytokines (interleukin [IL]-1beta, tumor necrosis factor [TNF]-alpha, and IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured in paired cerebrospinal fluid (CSF) and serum samples from patients with subacute sclerosing panencephalitis (SSPE), multiple sclerosis (MS), or other neurologic diseases (OND) by ELISA. IL-1beta was significantly increased in CSF of the SSPE group compared with levels in the MS or OND group. IL-1beta CSF/serum ratios were higher in the SSPE than in the MS or OND group. TNF-alpha and IL-6 levels were similar in the 3 groups. CSF sICAM-1 was higher in the SSPE group than in the MS or OND group. sICAM-1 CSF/serum ratios were higher in the SSPE than the OND group. The increased CSF/serum ratios of IL-1beta and sICAM-1 in SSPE indicate synthesis of IL-1beta and sICAM-1 in the central nervous system and may be important in the pathogenesis of disease.