Effect of Lipoxin A4 on Myocardial Ischemia Reperfusion Injury Following Cardiac Arrest in a Rabbit Model
Effect of Lipoxin A4 on Myocardial Ischemia Reperfusion Injury Following Cardiac Arrest in a Rabbit Model
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DOI：
10.1007/s10753-012-9567-x
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发表时间：
2013-04-01
期刊：
影响因子：
5.1
通讯作者：
Li, Siying
中科院分区：
文献类型：
--
作者：
Chen, Zhiqiao;Wu, Zhe;Li, Siying
在本研究中，我们研究了脂氧素A4对兔心脏骤停（CA）后心肌缺血-再灌注损伤（IRI）的影响。脂氧素A4是花生四烯酸在类花生酸中的代谢产物，因其抗炎活性而被称为“刹车信号”。观察各组大鼠心肌组织炎症因子（IL-1 β、IL-6、TNF-α、IL-10）、NF-κ B B p65、心肌梗死率、心肌细胞凋亡指数、心肌肌钙蛋白I（cTnI）、血流动力学及心肌结构的变化。脂氧素A4可抑制IL-1 β、IL-6和TNF-α的表达、梗死率、凋亡指数、血清cTnI和NF-κ B p65水平。同时，改善IL-10的表达、血流动力学、心肌结构和功能。提示脂氧素A4可减轻复苏后心肌IRI，其抗炎作用和抑制NF-κ B活化可能起重要作用。
In the present study, we investigated the effect of lipoxin A4 on myocardial ischemia-reperfusion injury (IRI) following cardiac arrest (CA) in a rabbit model. Lipoxin A4 is a metabolite of arachidonic acid in the eicosanoid, it is called "brake signal" for its anti-inflammatory activity. Some inflammatory factors (IL-1 beta, IL-6, TNF-alpha, and IL-10), NF-kappa B p65, infarct ratios, apoptotic index, cardiac troponin I (cTnI), hemodynamic and myocardial structures were measured or observed in different groups. Lipoxin A4 inhibits the expression of IL-1 beta, IL-6, and TNF-alpha, the values of the infarct ratios, apoptotic index, the level of serum cTnI and NF-kappa B p65. Meanwhile, it improves the expression of IL-10, hemodynamic, myocardial structure, and function. These indicate that lipoxin A4 mitigates postresuscitation myocardial IRI in which anti-inflammation and suppression of NF-kappa B activation may play an important role.