Insight Reconfigures Hippocampal-Prefrontal Memories
Insight Reconfigures Hippocampal-Prefrontal Memories
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DOI：
10.1016/j.cub.2015.01.033
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发表时间：
2015-03-30
期刊：
影响因子：
9.2
通讯作者：
Doeller, Christian F.
中科院分区：
文献类型：
--
作者：
Milivojevic, Branka;Vicente-Grabovetsky, Alejandro;Doeller, Christian F.
我们的记忆是非常动态的，一旦有新的信息出现，我们就可以重新解读过去。获得新奇的洞察力可以导致对以前不相关的事件进行心理重组，从而将它们联系到叙事中。海马体和内侧前额叶皮质(MPFC)支持部分重叠事件的整合，但重组记忆以形成连贯叙事的神经机制仍然难以捉摸。在这里，我们将fMRI与模拟人生3中栩栩如生的动画事件视频相结合，这些视频既可以融入叙事，也可以不融入叙事。我们发现，洞察力触发了叙事的新记忆表征的出现，并与后部海马区、mPFC和自传体记忆网络中关联事件表征之间的神经相似性增加有关。与此同时，与新建立的叙事记忆无关的事件被删除。伴随着这一过程的是，后部海马区和mPFC区非关联事件表征之间的神经差异性增加，并通过前部海马区的失配反应发出信号。我们的结果表明，洞察力导致了记忆空间内表征网络的神经重构，并对教育环境中的知识获取具有启示意义。
Our memories are remarkably dynamic and allow us to reinterpret the past once new information comes to light. Gaining novel insights can lead to mental reorganization of previously unrelated events, thus linking them into narratives. The hippocampus and medial prefrontal cortex (mPFC) support integration of partially overlapping events, but the neural mechanisms underlying the reorganization of memories for the formation of coherent narratives remain elusive. Here, we combine fMRI with The Sims 3 videos of life-like animated events, which could either be integrated into narratives or not. We show that insight triggers the emergence of de novo mnemonic representations of the narratives and is associated with increased neural similarity between linked event representations in the posterior hippocampus, mPFC, and autobiographical-memory network. Simultaneously, events irrelevant to the newly established memory of the narrative were pruned out. This process was accompanied by increased neural dissimilarity between non-linked event representations in the posterior hippocampus and mPFC and was additionally signaled by a mismatch response in the anterior hippocampus. Our results demonstrate that insight leads to neural reconfiguration of representational networks within a memory space and have implications for knowledge acquisition in educational settings.