Interleukin-5, interleukin-6, interferon induced protein-10, procalcitonin and C-reactive protein among mechanically ventilated severe community-acquired viral and bacterial pneumonia patients.
Interleukin-5, interleukin-6, interferon induced protein-10, procalcitonin and C-reactive protein among mechanically ventilated severe community-acquired viral and bacterial pneumonia patients.
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DOI：
10.1016/j.cyto.2018.07.019
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发表时间：
2019-01
期刊：
影响因子：
3.8
通讯作者：
Syrjälä HT
中科院分区：
文献类型：
--
作者：
Karhu J;Ala-Kokko TI;Vuorinen T;Ohtonen P;Julkunen I;Syrjälä HT
与其他病因相比，病毒性SCAP中的IL-5水平更高。混合病因SCAP的IP-10值最高，但无统计学显著性。TNF-α在组间无显著差异。降钙素原水平在混合病因的SCAP中最高。对45例重症监护室（ICU）机械通气的、3个不同病原学组中已知微生物病原学的重症社区获得性肺炎（SCAP）患者的血清细胞因子水平进行了评估。在研究入选后0、12、24、48、72和96 h时间点采集血液样本，用于检测C反应蛋白（CRP）、降钙素原（PCT）、白细胞介素（IL）-5、IL-6、IL-10、人干扰素γ诱导蛋白（IP）-10和TNF-α（肿瘤坏死因子α）。在45例机械通气SCAP患者中，有21例（43%）纯细菌感染（细菌组，BG），5例（10%）纯病毒感染（病毒组，VG），19例（39%）混合细菌-病毒感染（混合组，MG）。CRP和PCT水平在MG中显著较高，并且所有组的值均随时间而降低。PCT在时间和组分析中也存在差异（P = 0.001），MG中最高。VG组IL-5水平显著高于其他各组（P时间= 0.001，P组= 0.051，P时间组= 0.016）。IL-6和IP-10水平随时间降低（P时间= 0.003和P时间= 0.021），但组间无差异。具有病毒病因的SCAP患者具有较高的IL-5水平。病毒和细菌混合组患者的PCT高于其他病因。
IL-5 levels were higher in viral SCAP compared to other etiologies. Mixed etiology SCAP had the highest but not statistically significant IP-10 values. There were no significant differences in TNF-α between groups. Procalcitonin levels were highest in SCAP with mixed etiology. The serum cytokine levels among 45 mechanically ventilated, intensive care unit (ICU)-treated severe community-acquired pneumonia (SCAP) patients with known microbial etiology in three different etiology groups were assessed. Blood samples for C-reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-5, IL-6, IL-10, human interferon gamma induced protein (IP)-10, and TNF-α (tumor necrosis factor alpha) were collected at time points 0, 12, 24, 48, 72 and 96 h after study inclusion. There were 21 (43%) pure bacterial infections (bacterial group, BG), 5 (10%) pure viral infections (viral group, VG), and 19 (39%) mixed bacterial-viral infections (mixed group, MG) among 45 mechanically ventilated SCAP patients. CRP and PCT levels were significantly higher in the MG and values decreased with time in all groups. PCT differed also in time and group analysis (P = 0.001), the highest being in the MG. IL-5 levels were significantly higher in the VG compared to others (Ptime = 0.001, Pgroup = 0.051 and Ptimexgroup = 0.016). IL-6 and IP-10 levels decreased over time (Ptime = 0.003 and Ptime = 0.021), but there were no differences between groups. SCAP patients with viral etiology have higher IL-5 levels. Patients with mixed viral and bacterial group have higher PCT compared to other etiologies.
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DOI：
10.1186/cc10444
发表时间：
2011
期刊：
Critical care (London, England)
影响因子：
--
作者：
Cillóniz C;Ewig S;Ferrer M;Polverino E;Gabarrús A;Puig de la Bellacasa J;Mensa J;Torres A
通讯作者：
Torres A
影响因子：
4.6
作者：
Hoffmann J;Machado D;Terrier O;Pouzol S;Messaoudi M;Basualdo W;Espínola EE;Guillen RM;Rosa-Calatrava M;Picot V;Bénet T;Endtz H;Russomando G;Paranhos-Baccalà G
通讯作者：
Paranhos-Baccalà G
影响因子：
2.6
作者：
Matsumoto, Yuji;Kawamura, Yoshiki;Yoshikawa, Tetsushi
通讯作者：
Yoshikawa, Tetsushi
影响因子：
3.1
作者：
Ju YN;Yu KJ;Wang GN
通讯作者：
Wang GN
影响因子：
3.2
作者：
Wu, CL;Chan, MC;Hsu, JY
通讯作者：
Hsu, JY