Human papillomavirus DNA in oral mucosal lesions
Human papillomavirus DNA in oral mucosal lesions
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DOI：
10.1086/339193
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发表时间：
2002-03-15
影响因子：
6.4
通讯作者：
Ammatuna, P
中科院分区：
文献类型：
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作者：
Giovannelli, L;Campisi, G;Ammatuna, P
本研究检测了121例不同类型口腔粘膜病变(鳞癌13例，恶性病变59例，良性糜烂性溃烂病变49例)和90例对照组口腔粘膜细胞中人乳头状瘤病毒(HPV)DNA的存在。采用套式聚合酶链式反应检测HPVDNA，DNA测序确定基因分型。HPV在癌中的感染率为61.5%，在潜在恶性病变中为27.1%，在糜烂性溃烂病变中为26.5%，在对照组中为5.5%。恶性或潜在恶性病变的风险与HPV相关，具有统计学意义。在86.5%的HPV阳性皮损中发现HPV-18，但与特定类型的皮损无关，在80%的HPV阳性对照受试者中发现HPV-18。HPV感染与年龄有关，但与性别、吸烟或饮酒无关；口腔病变的存在增加了HPV感染的风险。
This study determined the presence of human papillomavirus (HPV) DNA in oral mucosa cells from 121 patients with different types of oral mucosal lesions (13 squamous cell carcinomas, 59 potentially malignant lesions, 49 benign erosive ulcerative lesions) and from 90 control subjects. HPV DNA was detected by nested polymerase chain reaction, and genotype was determined by DNA sequencing. HPV prevalence was 61.5% in carcinomas, 27.1% in potentially malignant lesions, 26.5% in erosive ulcerative lesions, and 5.5% in control subjects. The risk of malignant or potentially malignant lesions was associated with HPV and was statistically significant. HPV-18 was found in 86.5% of HPV-positive lesions but was not associated with a particular type of lesion and was found in 80% of the HPV-positive control subjects. HPV infection was related to older age but not to sex, smoking, or alcohol use; the presence of lesions in the oral cavity increased the risk of HPV infection.