Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior.
Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior.
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DOI：
10.1523/jneurosci.0895-11.2011
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发表时间：
2011-07-13
期刊：
影响因子：
--
通讯作者：
Adcock RA
中科院分区：
文献类型：
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作者：
Ballard IC;Murty VP;Carter RM;MacInnes JJ;Huettel SA;Adcock RA
大脑如何将潜在奖励信号转化为获得奖励的动机？获得奖励的动机被认为取决于中脑（特别是腹侧被盖区，VTA），丘脑核（NAcc）和背外侧前额叶皮层（dlPFC），但目前尚不清楚这些区域之间的相互作用如何与奖励动机行为相关。为了研究动机对这些奖励反应区域及其相互作用的影响，我们使用动态因果模型（DCM）来分析人类执行一项旨在隔离奖励预期的简单任务的功能磁共振成像（fMRI）数据。当人类参与者期待并准备获得奖励的机会时，功能磁共振成像的使用允许同时测量多个大脑区域，从而可以描述奖励信息如何改变动机驱动的生理学。此外，我们模拟了外部奖励线索对该网络中因果关系的影响，从而阐述了生理学，连接性和动机之间的联系。具体来说，我们的研究结果表明，dlPFC是唯一的入口点的信息奖励在这个网络中，预期的奖励的可用性引起腹侧被盖区激活只通过其对dlPFC的影响。因此，预期奖励直接增加了dlPFC的激活，而它只间接影响腹侧被盖区和NAcc，通过增强dlPFC内在的弱或不活跃的途径。我们的研究结果的方向性前额叶的多巴胺能区域的影响，在奖励预期建议的模型中，dlPFC集成和传输代表性的奖励中脑边缘和中皮层多巴胺系统，从而启动动机行为。
How does the brain translate information signaling potential rewards into motivation to get them? Motivation to obtain reward is thought to depend on the midbrain, (particularly the ventral tegmental area, VTA), the nucleus accumbens (NAcc), and the dorsolateral prefrontal cortex (dlPFC), but it is not clear how the interactions amongst these regions relate to reward-motivated behavior. To study the influence of motivation on these reward-responsive regions and on their interactions, we used Dynamic Causal Modeling (DCM) to analyze functional magnetic resonance imaging (fMRI) data from humans performing a simple task designed to isolate reward anticipation. The use of fMRI permitted the simultaneous measurement of multiple brain regions while human participants anticipated and prepared for opportunities to obtain reward, thus allowing characterization of how information about reward changes physiology underlying motivational drive. Further, we modeled the impact of external reward cues on causal relationships within this network, thus elaborating a link between physiology, connectivity, and motivation. Specifically, our results indicated that dlPFC was the exclusive entry point of information about reward in this network, and that anticipated reward availability caused VTA activation only via its effect on the dlPFC. Anticipated reward thus increased dlPFC activation directly, whereas it influenced VTA and NAcc only indirectly, by enhancing intrinsically weak or inactive pathways from the dlPFC. Our findings of a directional prefrontal influence on dopaminergic regions during reward anticipation suggest a model in which the dlPFC integrates and transmits representations of reward to the mesolimbic and mesocortical dopamine systems, thereby initiating motivated behavior.