Environmental Regulation of Yersinia Pathophysiology.
Environmental Regulation of Yersinia Pathophysiology.
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耶尔森氏菌病理生理学的环境调节
DOI：
10.3389/fcimb.2016.00025
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发表时间：
2016
影响因子：
5.7
通讯作者：
Francis MS
中科院分区：
文献类型：
--
作者：
Chen S;Thompson KM;Francis MS
耶尔森氏菌致病的标志包括在表面上形成生物膜的能力、与真核靶细胞建立紧密接触的能力以及劫持真核细胞信号传导并接管战略细胞过程控制的能力。这些毒力性状中的许多已经被很好地描述。然而，同样重要的是知识的局限性和全球性的监管网络，共同合作，以决定空间和时间的毒力基因表达的控制。这篇综述的目的是将历史观察与新发现，以提供分子的洞察力，这些监管机制如何迅速响应环境通量，以管理严格控制致病性耶尔森氏菌的毒力基因表达。
Hallmarks of Yersinia pathogenesis include the ability to form biofilms on surfaces, the ability to establish close contact with eukaryotic target cells and the ability to hijack eukaryotic cell signaling and take over control of strategic cellular processes. Many of these virulence traits are already well-described. However, of equal importance is knowledge of both confined and global regulatory networks that collaborate together to dictate spatial and temporal control of virulence gene expression. This review has the purpose to incorporate historical observations with new discoveries to provide molecular insight into how some of these regulatory mechanisms respond rapidly to environmental flux to govern tight control of virulence gene expression by pathogenic Yersinia.
影响因子：
4.2
作者：
Delihas N
通讯作者：
Delihas N