Single-exposure contrast enhanced spectral mammography (Conference Presentation)
Single-exposure contrast enhanced spectral mammography (Conference Presentation)
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单次曝光对比增强光谱乳腺摄影（会议演示）
DOI：
10.1117/12.2513515
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Das, Mini
中科院分区：
文献类型：
--
作者：
Torrico, Raul C.;Das, Mini
正在实施对比度增强光谱乳腺X射线摄影（CESM），以克服传统乳腺X射线摄影的局限性，其中肿瘤可视化被重叠的腺体组织阻挡。CESM通过减去两个图像来利用造影剂的光谱特性，一个图像在K边缘能量之上获得，另一个图像在K边缘能量之下获得。最常见的方法需要双曝光，其中利用不同的入射光谱获得两个图像。然而，这是以增加患者剂量和对运动伪影的敏感性为代价的。我们建议使用光子计数光谱探测器，同时获得多个图像与单次曝光。使用宽面积CdTe Medipix 3RX探测器在拟人乳房成像体模中采集碘造影剂图像证明了这一点。检测器中的电子阈值取代了传统的物理滤波器。我们的研究结果表明，单次曝光CESM检测碘浓度低至2.5 mg/mL的10 mm直径的目标在5 cm厚的异质背景。这些结果证明了光子计数探测器用于低剂量对比度增强乳腺摄影的可行性。
Contrast-enhanced spectral mammography (CESM) is being implemented to overcome the limitations of conventional mammography where tumor visualization is obstructed by overlapping glandular tissue. CESM exploits the spectral properties of a contrast agent by subtracting two images one obtained above and other below the K-edge energy. The most common approach requires dual-exposure where two images are obtained with differ- ent incident spectra. However, this comes at the expense of increased patient dose and susceptibility to motion artifacts. We propose the use of photon counting spectral detectors to simultaneously obtain multiple images with single-exposure. This is demonstrated using a wide area CdTe Medipix3RX detector to acquire images of iodine contrast agent in an anthropomorphic breast imaging phantom. The electronic thresholds in the detector replace the traditional physical filters. Our results show single-exposure CESM for the detection of iodine with concentrations as low as 2.5 mg/mL of a 10 mm diameter target in a 5 cm thick heterogeneous background. These results demonstrate the viability of photon counting detectors for low dose contrast-enhanced mammography.