ProtaBank: A repository for protein design and engineering data.
ProtaBank: A repository for protein design and engineering data.
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ProtaBank：蛋白质设计和工程数据的存储库。
DOI：
10.1002/pro.3585
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Olafson,BarryD
中科院分区：
文献类型：
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作者：
Wang,ConnieY;Chang,PaulM;Ary,MarieL;Allen,BenjaminD;Chica,RobertoA;Mayo,StephenL;Olafson,BarryD
我们介绍了ProtaBank，这是一个存储库，用于在主动维护和更新的数据库中存储、查询、分析和共享蛋白质设计和工程数据。ProtaBank提供了一种格式来描述和比较所有类型的蛋白质突变数据，涵盖了广泛的特性和技术。它以用户友好的Web界面和编程层为特色，简化了数据存储并允许批量输入和查询。数据库模式设计结合了报告蛋白质序列和实验数据的标准格式，便于跨不同数据集比较结果。提供了一套分析和可视化工具，以促进发现，指导未来设计，并对新的预测工具和算法进行基准测试和培训。ProtaBank将通过存储和保护新生成的数据，允许从现有文献中快速搜索和识别相关数据，并探索不同数据集之间的相关性，为蛋白质工程界提供宝贵的资源。ProtaBank邀请研究人员向数据库贡献数据，使其可供搜索和分析。ProtaBank的网址是：https://protabank.org.。
We present ProtaBank, a repository for storing, querying, analyzing, and sharing protein design and engineering data in an actively maintained and updated database. ProtaBank provides a format to describe and compare all types of protein mutational data, spanning a wide range of properties and techniques. It features a user‐friendly web interface and programming layer that streamlines data deposition and allows for batch input and queries. The database schema design incorporates a standard format for reporting protein sequences and experimental data that facilitates comparison of results across different data sets. A suite of analysis and visualization tools are provided to facilitate discovery, to guide future designs, and to benchmark and train new predictive tools and algorithms. ProtaBank will provide a valuable resource to the protein engineering community by storing and safeguarding newly generated data, allowing for fast searching and identification of relevant data from the existing literature, and exploring correlations between disparate data sets. ProtaBank invites researchers to contribute data to the database to make it accessible for search and analysis. ProtaBank is available at https://protabank.org.