Math1:: An essential gene for the generation of inner ear hair cells
Math1:: An essential gene for the generation of inner ear hair cells
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DOI：
10.1126/science.284.5421.1837
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发表时间：
1999-06-11
期刊：
影响因子：
56.9
通讯作者：
Zoghbi, HY
中科院分区：
文献类型：
--
作者：
Bermingham, NA;Hassan, BA;Zoghbi, HY
哺乳动物的内耳包含耳蜗和前庭器官，分别负责听力和平衡。这些感觉器官的上皮细胞含有毛细胞，其功能是机械感受器，以刺激声音和头部运动。毛细胞发育和分化的分子机制知之甚少。Math 1是果蝇前神经基因的小鼠同源物，在内耳感觉上皮中表达。胚胎Math 1-null小鼠未能产生耳蜗和前庭毛细胞。因此，这种基因是毛细胞发生所必需的。
The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion. The molecular mechanisms underlying hair cell development and differentiation are poorly understood. Math1, a mouse homolog of the Drosophila proneural gene atonal, is expressed in inner ear sensory epithelia. Embryonic Math1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells.