Neural correlates of internal-model loading
Neural correlates of internal-model loading
复制标题
DOI：
10.1016/j.cub.2006.10.051
复制
发表时间：
2006-12-19
期刊：
影响因子：
9.2
通讯作者：
Flanagan, J. Randall
中科院分区：
文献类型：
--
作者：
Bursztyn, Lulu L. C. D.;Ganesh, G.;Flanagan, J. Randall
熟练的物体操作需要将作用力与运动联系起来的物体动力学知识或内部模型[1 - 4]，而我们处理无数物体的能力[5 - 6]表明大脑保持着多种模型[7 - 9]。最近的行为研究表明，一旦学习，具有新动态的物体的内部模型可以随着物体的抓取和释放而迅速被招募和解除[10 - 12]。我们使用事件相关的功能磁共振成像来研究神经活动，这些神经活动与抓住一个物体有关，该物体具有最近学习的动力学，为延迟后移动它做准备。受试者还进行了两个控制任务，他们要么移动没有对象在手或施加等距力的对象。在所有试验中，受试者都收到了一个提示，指示他们在5 - 10秒后收到一个go信号后执行哪个任务。我们研究了BOLD反应之间的时间间隔的线索和去，并评估了连接的两个对比形成的主要任务，每个控制。分析显示，同侧小脑和对侧和补充运动区的显着活动。我们建议，这些区域参与内部模型招聘运动执行的准备。
Skilled object manipulation requires knowledge, or internal models, of object dynamics relating applied force to motion [1-4], and our ability to handle myriad objects [5-6] indicates that the brain maintains multiple models [7-9]. Recent behavioral studies have shown that once learned, an internal model of an object with novel dynamics can be rapidly recruited and derecruited as the object is grasped and released [10-12]. We used event-related fMRI to investigate neural activity linked to grasping an object with recently learned dynamics in preparation for moving it after a delay. Subjects also performed two control tasks in which they either moved without the object in hand or applied isometric forces to the object. In all trials, subjects received a cue indicating which task to perform in response to a go signal delivered 5-10 s later. We examined BOLD responses during the interval between the cue and go and assessed the conjunction of the two contrasts formed by comparing the primary task to each control. The analysis revealed significant activity in the ipsilateral cerebellum and the contralateral and supplementary motor areas. We propose that these regions are involved in internal-model recruitment in preparation for movement execution.