Energy constraints on the evolution of gene expression
Energy constraints on the evolution of gene expression
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DOI：
10.1093/molbev/msi126
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发表时间：
2005-06-01
影响因子：
10.7
通讯作者：
Wagner, A
中科院分区：
文献类型：
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作者：
Wagner, A
我在这里估计了酵母酿酒酵母中数千个基因的基因表达变化的能量成本。基因表达的加倍，因为它发生在一个基因复制事件，是显着选择对所有基因的表达数据是可用的。它具有s > 10（-5）的中值选择劣势，比选择系数= 1.47 × 10（-7）大几倍，低于该选择系数，遗传漂变支配突变体的命运。当单独考虑时，信使RNA表达或蛋白质表达的增加超过2倍对大多数基因来说也具有显著的能量成本。这意味着转录和翻译速率的进化不是一个进化中性的过程。他们是在积极的选择反对他们。我的估计是基于酵母S.酿酒酵母以及关于生物合成氨基酸和核苷酸的能量成本的信息。
I here estimate the energy cost of changes in gene expression for several thousand genes in the yeast Saccharomyces cerevisiae. A doubling of gene expression, as it occurs in a gene duplication event, is significantly selected against for all genes for which expression data is available. It carries a median selective disadvantage of s > 10(-5), several times greater than the selection coefficients = 1.47 X 10(-7) below which genetic drift dominates a mutant's fate. When considered separately, increases in messenger RNA expression or protein expression by more than a factor 2 also have significant energy costs for most genes. This means that the evolution of transcription and translation rates is not an evolutionarily neutral process. They are under active selection opposing them. My estimates are based on genome-scale information of gene expression in the yeast S. cerevisiae as well as information on the energy cost of biosynthesizing amino acids and nucleotides.