Photoresponsive amphiphilic azobenzene-PEG self-assembles to form supramolecular nanostructures for drug delivery applications
Photoresponsive amphiphilic azobenzene-PEG self-assembles to form supramolecular nanostructures for drug delivery applications
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DOI：
10.1039/c5ra26658k
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发表时间：
2016-01-01
期刊：
影响因子：
3.9
通讯作者：
Kumar, Pradeep
中科院分区：
文献类型：
--
作者：
Yadav, Santosh;Deka, Smriti Rekha;Kumar, Pradeep
自组装智能纳米结构已经成为药物递送应用的受控和位点特异性系统。通过4-（4-异硫氰酸基苯偶氮）-N，N-二甲基苯胺（ITPADA）与生物相容性功能化聚乙二醇在水溶液中自组装形成纳米结构，合成了一系列两亲性聚合物：Azo-PEG-NHBoc、Azo-PEG-NH 2和Azo-PEG-Gn。通过DLS和TEM测量研究了光控可逆组装和拆卸，以及酶介导的纳米结构的形态变化。疏水性药物在核中的包埋及其在外部刺激如光和酶的影响下的释放证明了这种纳米结构在药物递送应用中的潜力。
Self-assembled smart nanostructures have emerged as controlled and site-specific systems for drug delivery applications. An amphiphilic polymer series, Azo-PEG-NHBoc, Azo-PEG-NH2 and Azo-PEG-Gn, was formed by the reaction of 4-(4-isothiocyanatophenylazo)-N, N-dimethylaniline (ITPADA) with biocompatible functionalized polyethylene glycol which self-assembled in aqueous solutions to form nanostructures. Light-controlled reversible assembly and disassembly, and enzyme-mediated morphological changes in the nanostructures were investigated by DLS and TEM measurements. Entrapment of hydrophobic drugs in the core and their release under the influence of external stimuli such as light and enzyme demonstrated the potential of such nanostructures in drug delivery applications.