SYMPOSIUM ON COLONIC FUNCTION - ELECTROPHYSIOLOGY OF COLON
SYMPOSIUM ON COLONIC FUNCTION - ELECTROPHYSIOLOGY OF COLON
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DOI：
10.1136/gut.16.4.298
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发表时间：
1975-01-01
期刊：
影响因子：
24.5
通讯作者：
DANIEL, EE
中科院分区：
文献类型：
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作者：
DANIEL, EE
分析大肠平滑肌和神经的电生理学的一种方法是将它们中的一小部分作为平滑肌组织的例子进行检查，而不考虑整个器官的功能。另一种方法，更相关的临床问题，涉及分析器官的组成部分是如何控制和整合，以形成一个功能单位。大肠将其从回肠接收的半液体内容物转移到直肠，以允许电解质和水的提取以及途中成分的其他变化。由于内容物从直肠排出通常是周期性的现象，而从回肠排出的输入也可能是周期性的，因此输入和输出之间一定存在某种耦合;而且还必须有一个控制系统，以提供结肠内容物在转运过程中的有序延迟和运动。为了了解大肠转运的控制系统，一个系统的方法似乎是必要的。我认为，我们应该开始分析其肌肉成分可以执行的反应范围（丹尼尔，1973）。这需要考虑在正常和异常运动活动期间大肠肌肉组织的自发电和机械活动的起源和整合。一个问题很快就出现了：哪些反应是由平滑肌单独发起和整合的？阐明这个问题导致肌源性控制系统的特性的表征。如果完成，该表征将提供关于细胞电活动、肌肉层中的细胞间耦合和层间耦合以及这些活动转化为机械响应的信息。许多胃肠道肌源性控制系统，特别是胃和小肠的肌源性控制系统（参见丹尼尔，1973; Sarna，丹尼尔，and Kingma，1971，1972 a，B，and c），已被表征为相互耦合松弛的肌源性系统
One approach to an analysis of the electrophysiology of smooth muscle and nerves of the large bowel is to examine small bits of them as examples of smooth muscle tissues, without any consideration of the functions of the whole organ. Another approach, more relevant to clinical problems, involves analysis of how the components of the organ are controlled and integrated to form a functional unit. The large bowel transfers the semiliquid contents it receives from the ileum to the rectum in such a way as to allow for extraction of electrolytes and water and for other changes in composition en route. Since evacuation of contents from the rectum is usually a periodic phenomenon, and input by evacuation from the ileum is probably also periodic, there must be coupling in some way between input and output; and there must also be a system of controls to provide for orderly delays and movements of the colonic contents during transit. To understand the control system for transit in the large bowel, a systematic approach seems warranted. I believe one should begin with an analysis of the range of responses which its muscle components can execute (Daniel, 1973). This requires consideration of the origin and integration of spontaneous electrical and mechanical activity of the musculature of the large bowel during normal and abnormal motor activity. A question soon arises: Which responses are initiated and integrated by the smooth muscle alone? Answering this question leads to characterization of the properties of the myogenic control system. If complete, this characterization would provide information about the cellular electrical activities, cell-to-cell coupling in muscle layers and coupling between layers, and the translation of these activities into mechanical responses. A number of gastrointestinal myogenic control systems, particularly of stomach and small bowel (see Daniel, 1973; Sarna, Daniel, and Kingma, 1971, 1972a, b, and c), have been characterized as myogenic systems of mutually coupled relaxation