Lipids in RA: Is Less Not Necessarily More?
Lipids in RA: Is Less Not Necessarily More?
复制标题
DOI：
10.1007/s11926-018-0715-7
复制
发表时间：
2018-02-01
影响因子：
5
通讯作者：
Liao, Katherine P.
中科院分区：
文献类型：
--
作者：
Plutzky, Jorge;Liao, Katherine P.
综述目的在类风湿关节炎（RA）中，血脂水平是动态的，可以随着炎症的变化而波动。炎症的减少（最常见的是缓解疾病抗风湿药物 (DMARD) 治疗的结果）与总胆固醇 (TC) 和低密度脂蛋白胆固醇 (LDL-C) 的增加有关。在这篇综述中，我们讨论了新的证据，揭示了随着炎症变化观察到的脂质水平变化的潜在机制。最新发现血液中测得的脂质水平是合成与分解代谢或吸收之间平衡的结果。最近对活动性 RA 的人体研究表明，与一般人群的预期速率相比，脂质的分解代谢速率高于预期。 DMARD 治疗似乎可以使分解代谢率恢复到基线，从而导致血脂明显增加。总结通过控制炎症和 RA 治疗观察到的血脂增加表明体内平衡已恢复。目前正在进行研究，以了解控制炎症导致血脂水平升高时对 RA 心血管风险的总体影响。
Purpose of Review In rheumatoid arthritis (RA), lipid levels are dynamic and can fluctuate along with changes in inflammation. A reduction in inflammation, most commonly as a result of disease-modifying anti-rheumatic drug (DMARD) therapy, is associated with increases in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). In this review, we discuss new evidence shedding light on the potential mechanism underlying changes in lipid levels observed with changes in inflammation.Recent Findings Measured lipid levels in the blood are a result of a balance between synthesis and catabolism or absorption. Recent human studies in active RA show that the catabolic rates of lipids are higher than expected compared to expected rates in the general population. DMARD therapy appears to allow a return to baseline lower catabolic rates, resulting in an apparent increase in lipids.Summary Increases in lipids observed with control of inflammation and RA treatment suggest a return to homeostasis. Studies are underway to understand the overall impact on cardiovascular risk in RA when lipid levels increase as a result of controlling inflammation.