Repetitive transcranial magnetic stimulation for refractory symptoms in schizophrenia
Repetitive transcranial magnetic stimulation for refractory symptoms in schizophrenia
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DOI：
10.1097/yco.0b013e3283366657
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发表时间：
2010-03-01
影响因子：
6.9
通讯作者：
Daskalakis, Zafiris J.
中科院分区：
文献类型：
--
作者：
Blumberger, Daniel M.;Fitzgerald, Paul B.;Daskalakis, Zafiris J.
综述目的精神分裂症是一种与相当程度的治疗抵抗和次优治疗反应相关的疾病。近年来，新的脑刺激技术已被确定为精神分裂症和相关疾病的潜在治疗方法。几项已发表的研究评估了重复经颅磁刺激（rTMS）在精神分裂症患者中的应用。最近的发现大多数已发表的研究集中在使用低频rTMS治疗难治性幻听。这些研究支持刺激颞顶皮层的有效性。其他几项研究评估了对前额叶皮层的高频刺激在治疗阴性症状中的作用。新的协议，以治疗幻听已经试点和病例报告正在出现的使用维护rTMS治疗auditory hallowings.SummaryOverall，rTMS研究已经证明了一些承诺，在精神分裂症的治疗。然而，需要更多的研究来描绘这种技术在临床实践中的作用，并探索新的刺激技术，最终可能导致改善治疗效果。
Purpose of reviewSchizophrenia is an illness associated with a substantial degree of treatment resistance and suboptimal therapeutic response. In recent years, novel brain stimulation technologies have been identified as potential treatments for schizophrenia and related disorders. Several published studies have assessed the use of repetitive transcranial magnetic stimulation (rTMS) in patients with schizophrenia.Recent findingsMost published studies have focused on the use of low-frequency rTMS to treat refractory auditory hallucinations. These studies support the efficacy of stimulation over the temporoparietal cortex. Several other studies have assessed high-frequency stimulation of the prefrontal cortex in the treatment of negative symptoms. Novel protocols to treat auditory hallucinations have been piloted and case reports are emerging on the use of maintenance rTMS to treat auditory hallucinations.SummaryOverall, rTMS studies have demonstrated some promise in the treatment of schizophrenia. However, more research is required to delineate the role of this technique in clinical practice and to explore novel stimulation techniques that may ultimately lead to improved therapeutic efficacy.