Microvascular endothelial cells of the corpus luteum.
Microvascular endothelial cells of the corpus luteum.
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DOI：
10.1186/1477-7827-1-89
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发表时间：
2003-11-10
期刊：
影响因子：
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通讯作者：
Spanel-Borowski, Katherina
中科院分区：
文献类型：
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作者：
Davis, John S;Rueda, Bo R;Spanel-Borowski, Katherina
黄体中毛细血管床的循环性质提供了一个独特的实验模型来检查内皮细胞的生命周期，涉及血管生成、血管成熟和血管退化的离散生理调节步骤。发育中的窦状卵泡的颗粒细胞和卵泡膜细胞以及黄体的类固醇生成细胞产生并响应血管生成因子和血管活性肽。排卵后，黄体发育早期阶段的新血管形成与肿瘤形成期间观察到的快速血管生成进行了比较。在光谱的另一端，微血管内皮细胞是在黄体退化开始时经历凋亡的第一个细胞。通过对内皮细胞的体内外研究，对黄体内皮细胞的形态和功能有了重要的认识。内皮细胞与包含黄体功能单位的细胞，即，其它血管细胞、类固醇生成细胞和免疫细胞。本文综述了黄体中内皮细胞的类型及其在黄体发育和退化中的作用。现有的证据表明，黄体的微血管内皮细胞是不一样的，并且在血管生成和血管消退的过程中可能是不同的。黄体内皮素-1和肾素-血管紧张素系统产生的血管活性肽的贡献进行了讨论的背景下，在黄体形成和退化的内皮细胞的功能。两种细胞因子，肿瘤坏死因子α和干扰素γ的能力，作为旁分泌介质的内皮细胞功能在血管退行性病变的评估。最后，讨论了趋化因子作为一种重要的内皮细胞分泌产物，有助于招募嗜酸性粒细胞和巨噬细胞。该综述强调了卵巢微血管内皮细胞的未来研究领域。考虑到血管功能障碍可能在生殖过程中发挥作用，如卵巢衰竭，多囊卵巢综合征（PCOS）和卵巢过度刺激综合征（OHSS），针对黄体内皮细胞的研究的潜在临床应用是有趣的。
The cyclic nature of the capillary bed in the corpus luteum offers a unique experimental model to examine the life cycle of endothelial cells, involving discrete physiologically regulated steps of angiogenesis, blood vessel maturation and blood vessel regression. The granulosa cells and theca cells of the developing antral follicle and the steroidogenic cells of the corpus luteum produce and respond to angiogenic factors and vasoactive peptides. Following ovulation the neovascularization during the early stages of corpus luteum development has been compared to the rapid angiogenesis observed during tumor formation. On the other end of the spectrum, the microvascular endothelial cells are the first cells to undergo apoptosis at the onset of corpus luteum regression. Important insights on the morphology and function of luteal endothelial cells have been gained from a combination of in vitro and in vivo studies on endothelial cells. Endothelial cells communicate with cells comprising the functional unit of the corpus luteum, i.e., other vascular cells, steroidogenic cells, and immune cells. This review is designed to provide an overview of the types of endothelial cells present in the corpus luteum and their involvement in corpus luteum development and regression. Available evidence indicates that microvascular endothelial cells of the corpus luteum are not alike, and may differ during the process of angiogenesis and angioregression. The contributions of vasoactive peptides generated by the luteal endothelin-1 and the renin-angiotensin systems are discussed in context with the function of endothelial cells during corpus luteum formation and regression. The ability of two cytokines, tumor necrosis factor alpha and interferon gamma, are evaluated as paracrine mediators of endothelial cell function during angioregression. Finally, chemokines are discussed as a vital endothelial cell secretory products that contribute to the recruitment of eosinophils and macrophages. The review highlights areas for future investigation of ovarian microvascular endothelial cells. The potential clinical applications of research directed on corpus luteum endothelial cells are intriguing considering reproductive processes in which vascular dysfunctions may play a role such as ovarian failure, polycystic ovary syndrome (PCOS), and ovarian hyperstimulation syndrome (OHSS).