G20210A prothrombin gene polymorphism and coronary ischaemic syndromes: a phenotype-specific meta-analysis of 12 034 subjects
G20210A prothrombin gene polymorphism and coronary ischaemic syndromes: a phenotype-specific meta-analysis of 12 034 subjects
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DOI：
10.1136/heart.90.1.82
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发表时间：
2004-01-01
期刊：
影响因子：
5.7
通讯作者：
Andreotti, F
中科院分区：
文献类型：
--
作者：
Burzotta, F;Paciaroni, K;Andreotti, F
目的：探讨 G20210A 凝血酶原基因变异与不同形式的缺血性心脏病之间可能存在的联系。设计：对 2002 年 3 月发表的 19 项研究进行表型特异性荟萃分析，其中包括全球 4944 名患者和 7090 名对照者。从每项研究中提取样本量、纳入标准、地理位置、临床表现、年龄、心血管危险因素和血管造影疾病范围。根据 Mantel-Haenszel 进行分析。 结果：总体而言，与 20210A 等位基因相关的未明确缺血性心脏病的比值比 (OR) 为 1.21（95% 置信区间 (CI) 0.99 至 1.59，n = 12 034）。急性冠脉综合征（不稳定型心绞痛和心肌梗死）和无年龄限制的心肌梗死也有类似的结果（OR 1.24，95% CI 0.98 至 1.63，n = 10 240；OR 1.19，95% CI 0.93 至 1.58，n = 9765）。男性和女性受试者的效果相似。在 1931 名 55 岁受试者中，心肌梗死的 OR 增加至 1.77（95% CI 1.16 至 3.42），在 1359 名受试者中
Objective: To investigate the possible link between the G20210A prothrombin gene variant and different forms of ischaemic heart disease.Design: Phenotype-specific meta-analysis of 19 studies published within March 2002, globally including 4944 patients and 7090 controls. Sample size, inclusion criteria, geographical location, clinical presentation, age, cardiovascular risk factors, and angiographic extent of disease were extracted from each study. Analyses were done according to Mantel-Haenszel.Results: Overall, the odds ratio (OR) for unspecified ischaemic heart disease associated with the 20210A allele was 1.21 (95% confidence interval (CI) 0.99 to 1.59, n = 12 034). Similar findings were seen for acute coronary syndromes ( unstable angina and myocardial infarction) and for myocardial infarction without age limits (OR 1.24, 95% CI 0.98 to 1.63, n = 10 240; and OR 1.19, 95% CI 0.93 to 1.58, n = 9765). The effects were similar in male and female subjects. In the 1931 subjects, 55 years of age, the OR for myocardial infarction increased to 1.77 (95% CI 1.16 to 3.42) and in the 1359 subjects