Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex
Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex
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DOI：
10.1073/pnas.0701944104
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发表时间：
2007-05-01
影响因子：
11.1
通讯作者：
Merzenich, M. M.
中科院分区：
文献类型：
--
作者：
Kenet, T.;Froemke, R. C.;Merzenich, M. M.
非共面多氯联苯广泛分布于人体环境和组织中。在这里，一个典型的非共面多氯联苯在妊娠期间和随后的三个哺乳周内喂给大鼠。虽然幼犬的听觉敏感性和脑后听觉反应正常，但暴露导致初级听觉皮层（A1）发育异常。All的形状不规则，并以内部无反应区为特征，其地形组织在大约一半的暴露幼崽中严重异常或逆转，所有神经元的神经元抑制与兴奋的平衡被扰乱，并且作为正常产后听觉系统发育基础的关键时期可塑性显着改变。这些发现表明，发育过程中暴露于这类环境污染物会改变大脑皮层的发育。我们提出，暴露于非共面多氯联苯可能导致常见的发育障碍，特别是在调节大脑抑制和兴奋比例的神经递质系统遗传失衡的人群中。我们的结论是，人类暴露于非共面多氯联苯对健康的影响值得更仔细地检查。
Noncoplanar polychlorinated biphenyls (PCBs) are widely dispersed in human environment and tissues. Here, an exemplar noncoplanar PCB was fed to rat dams during gestation and throughout three subsequent nursing weeks. Although the hearing sensitivity and brainstern auditory responses of pups were normal, exposure resulted in the abnormal development of the primary auditory cortex (A1). All was irregularly shaped and marked by internal nonresponsive zones, its topographic organization was grossly abnormal or reversed in about half of the exposed pups, the balance of neuronal inhibition to excitation for All neurons was disturbed, and the critical period plasticity that underlies normal postnatal auditory system development was significantly altered. These findings demonstrate that developmental exposure to this class of environmental contaminant alters cortical development. It is proposed that exposure to noncoplanar PCBs may contribute to common developmental disorders, especially in populations with heritable imbalances in neurotransmitter systems that regulate the ratio of inhibition and excitation in the brain. We conclude that the health implications associated with exposure to noncoplanar PCBs in human populations merit a more careful examination.