Riboflavin (vitamin B2) and oxidative stress: a review
Riboflavin (vitamin B2) and oxidative stress: a review
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DOI：
10.1017/s0007114514000178
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发表时间：
2014-06-14
影响因子：
3.6
通讯作者：
Saedisomeolia, Ahmad
中科院分区：
文献类型：
--
作者：
Ashoori, Marziyeh;Saedisomeolia, Ahmad
氧化应激参与许多慢性疾病的发展。参与氧化应激减少的主要因素之一是增加抗氧化潜力。已知一些营养素如维生素C、维生素E和类胡萝卜素起抗氧化剂的作用;然而，核黄素是被忽视的抗氧化营养素之一，其可能独立地或作为谷胱甘肽氧化还原循环的组分具有抗氧化作用。在此，研究已经审查了核黄素的抗氧化性能和它的氧化应激减少的影响进行了审查。综述的研究结果证实了核黄素的抗氧化性质，并表明这种维生素可以保护身体免受氧化应激，特别是脂质过氧化和再灌注氧化损伤。核黄素保护机体免受氧化应激的机制可能归因于谷胱甘肽氧化还原循环，也可能归因于其他可能的机制，例如还原型核黄素转化为氧化形式。
Oxidative stress is involved in the development of many chronic diseases. One of the main factors involved in oxidative stress reduction is increased antioxidant potential. Some nutrients such as vitamin C, vitamin E and carotenoids are known to act as antioxidants; however, riboflavin is one of the neglected antioxidant nutrients that may have an antioxidant action independently or as a component of the glutathione redox cycle. Herein, studies that have examined the antioxidant properties of riboflavin and its effect on oxidative stress reduction are reviewed. The results of the reviewed studies confirm the antioxidant nature of riboflavin and indicate that this vitamin can protect the body against oxidative stress, especially lipid peroxidation and reperfusion oxidative injury. The mechanisms by which riboflavin protects the body against oxidative stress may be attributed to the glutathione redox cycle and also to other possible mechanisms such as the conversion of reduced riboflavin to the oxidised form.