Functional behaviour of skin allografts transplanted to rabbit deciduomata.
Functional behaviour of skin allografts transplanted to rabbit deciduomata.
复制标题
移植到兔蜕膜的同种异体皮肤移植物的功能行为。
作者：
M. Dodd;T. A. Andrew;J. S. Coles
研究了同种异体皮肤移植到兔蜕膜瘤的行为和命运，并与原位和皮下同种异体皮肤移植进行了比较。植入非致敏宿主蜕膜中的同种异体移植物存活，并且在移植后14天未显示出免疫排斥反应的证据。周围蜕膜组织未见淋巴细胞浸润。在非致敏宿主的子宫肌层中的同种异体移植物早在移植后7天就表现出免疫排斥反应。非致敏宿主的原位同种异体移植物在7至8天之间被排斥。植入预致敏宿主蜕膜的同种异体移植物在移植后6天存活且组织学健康，但在8天时存活率极低。由于排斥的移植物通常不被淋巴细胞浸润，因此可以得出结论，在没有细胞介导作用的情况下，体液抗体可能导致移植物的破坏。在预致敏宿主中的皮下同种异体移植物在移植后4至6天之间被排斥，并表现出经典的第二组类型的免疫反应。这些结果的意义进行了讨论，它作为建议，蜕膜，可能是因为它的结构，可能有助于限制其物质的入侵，由母体免疫活性细胞，从而有助于免疫特权性质的妊娠。
The behaviour and fate of allogenic skin transplanted to rabbit deciduomata was investigated and compared with orthotopic and subcutaneous allografts. Allografts implanted in the decidua of non-sensitized hosts were alive and showed no evidence of immunological rejection 14 days after grafting. The surrounding decidual tissue showed no infiltration by lymphocytes. Allografts in the myometrium of nonsensitized hosts demonstrated immunological rejection as early as 7 days post grafting. Orthotopic allografts on non-sensitized hosts were rejected between 7 and 8 days. Allografts implanted in the decidua of pre-sensitized hosts were alive and histologically healthy 6 days after grafting but showed minimal survival at 8 days. Since rejected grafts were not usually infiltrated with lymphocytes it was concluded that humoral antibody, in the absence of a cell mediated effect, may have procured the destruction of grafts. Subcutaneous allografts in pre-sensitized hosts were rejected between 4 and 6 days after grafting and demonstrated a classical second set type of immunological reaction. The significance of these results was discussed and it as suggested that the decidua, possibly because of its structure, may serve to restrict invasion of its substance by maternal immunocompetent cells thus contributing to the immunologically privileged nature of pregnancy.