Sex Differences in Trends of Incidence and Mortality of First-Ever Stroke in Rural Tianjin, China, From 1992 to 2012
Sex Differences in Trends of Incidence and Mortality of First-Ever Stroke in Rural Tianjin, China, From 1992 to 2012
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DOI：
10.1161/strokeaha.113.003899
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发表时间：
2014-06-01
期刊：
影响因子：
8.3
通讯作者：
Su, Ta-Chen
中科院分区：
文献类型：
--
作者：
Wang, Jinghua;Ning, Xianjia;Su, Ta-Chen
背景和目的——卒中发病率长期趋势的性别差异很少有报道。我们的目的是探讨 1992 年至 2012 年中国农村地区卒中发病率和死亡率的性别差异。方法 - 1992 年，招募了 14 920 名居民参加天津大脑研究，这是一项基于人群的卒中监测研究。每年登记中风事件和所有死亡。结果 - 从 1992 年到 2012 年，我们观察到 908 起中风事件（其中女性 366 起）。1992 年到 1998 年，女性明显比男性年轻（64+/-12 岁对比 68+/-11 岁）（P=0.024）。 1992年至1998年，男性每10万人年首次中风发病率为166例，1999年至2005年为227例，2006年至2012年为376例；女性的比率分别为86（19921998年）、148（1999-2005年）和264（2006-2012年）。从1992年到2012年，男性发病率每年增长5.8%，女性发病率每年增长8.0%。男女发病率显着下降：1992年至1998年为1.9，1999年至2005年为1.5，2006年至2012年为1.4。死亡率没有显着的性别差异。 2011年，女性肥胖症、糖尿病患病率、总胆固醇和甘油三酯水平、绝经年龄和育龄年龄同步上升。结论：近21年来，中国农村地区女性首次脑卒中发病率逐年显着上升，男女发病率呈下降趋势。这些结果表明，中风将成为未来几十年影响中国女性的主要疾病之一。
Background and Purpose-Sex differences in secular trends of stroke incidence are rarely reported. We aimed to explore sex differences in incidence and mortality of stroke in rural China from 1992 to 2012.Methods-In 1992, 14 920 residents were recruited to participate in the Tianjin Brain Study, a population-based study on stroke surveillance. Stroke events and all deaths were annually registered.Results-We observed 908 incident strokes (366 in women) from 1992 to 2012. Women were significantly younger than men (64+/-12 versus 68+/-11 years) in 1992 to 1998 (P=0.024). The incidence of first-ever stroke per 100 000 person-years for men was 166 in 1992 to 1998, 227 in 1999 to 2005, and 376 in 2006 to 2012; for women, the rates were 86 (19921998), 148 (1999-2005), and 264 (2006-2012). From 1992 to 2012, the incidence grew annually by 5.8% in men and 8.0% in women. The male/female incidence ratio declined significantly: 1.9 in 1992 to 1998, 1.5 in 1999 to 2005, and 1.4 in 2006 to 2012. There were no significant sex differences in mortality. The prevalence of obesity and diabetes mellitus, the levels of total cholesterol and triglycerides, and the age of menopause and reproductive years in women concurrently increased in 2011.Conclusions-There was a significant increase in the incidence of first-ever stroke in women annually and a declining trend in the male/female rate ratio in rural China during the past 21 years. These results suggest that stroke will become one of the major diseases affecting women in future decades in China.