Discordant transmission of bacteria and viruses from mothers to babies at birth
Discordant transmission of bacteria and viruses from mothers to babies at birth
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DOI：
10.1186/s40168-019-0766-7
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发表时间：
2019-12-10
期刊：
影响因子：
15.5
通讯作者：
Holtz, Lori R.
中科院分区：
文献类型：
--
作者：
Maqsood, Rabia;Rodgers, Rachel;Holtz, Lori R.
背景：人类肠道最早的微生物定殖者可能会对宿主产生终身影响。新生儿肠道细菌微生物群和病毒体最初是如何形成的还不是很清楚。为了更好地了解母亲肠道微生物群如何影响婴儿肠道微生物群的获取，我们研究了28对双胞胎婴儿及其母亲的早期生活中的细菌微生物群和病毒群。结果：婴儿细菌和病毒群落与他们相关的同卵双胞胎婴儿比不相关的婴儿更相似。我们发现，婴儿63%的细菌微生物群可以追溯到他们母亲的肠道微生物群。相比之下，他们的病毒社区中只有15%是从母亲那里获得的。传递途径没有确定有多少细菌微生物组或病毒体是从母亲传给婴儿的。然而，细菌-噬菌体的相互作用因分娩途径而改变。结论：母亲肠道微生物群显著影响婴儿肠道微生物群的获取。与病毒体的垂直传播相比，细菌微生物组的垂直传播要高得多。然而，母婴肠道细菌微生物群和病毒体之间的相似程度并不因分娩途径而异。双胞胎之间细菌微生物组和病毒体的相似性比不相关的双胞胎更大，这可能反映了共同的环境暴露。因此，主要微生物王国之间出生时世代间传播率的差异表明，这些微生物群落的基础是由不同的规则塑造的。
Background: The earliest microbial colonizers of the human gut can have life-long consequences for their hosts. Precisely how the neonatal gut bacterial microbiome and virome are initially populated is not well understood. To better understand how the maternal gut microbiome influences acquisition of the infant gut microbiome, we studied the early life bacterial microbiomes and viromes of 28 infant twin pairs and their mothers.Results: Infant bacterial and viral communities more closely resemble those of their related co-twin than unrelated infants. We found that 63% of an infant's bacterial microbiome can be traced to their mother's gut microbiota. In contrast, only 15% of their viral communities are acquired from their mother. Delivery route did not determine how much of the bacterial microbiome or virome was shared from mother to infant. However, bacteria-bacteriophage interactions were altered by delivery route.Conclusions: The maternal gut microbiome significantly influences infant gut microbiome acquisition. Vertical transmission of the bacterial microbiome is substantially higher compared to vertical transmission of the virome. However, the degree of similarity between the maternal and infant gut bacterial microbiome and virome did not vary by delivery route. The greater similarity of the bacterial microbiome and virome between twin pairs than unrelated twins may reflect a shared environmental exposure. Thus, differences of the inter-generation transmissibility at birth between the major kingdoms of microbes indicate that the foundation of these microbial communities are shaped by different rules.