Cutting edge:: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi
Cutting edge:: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi
复制标题
DOI：
10.4049/jimmunol.165.9.4797
复制
发表时间：
2000-11-01
影响因子：
4.4
通讯作者：
Bockenstedt, LK
中科院分区：
文献类型：
--
作者：
Kumar, H;Belperron, A;Bockenstedt, LK
CD1分子可以向T细胞呈递微生物脂质Ag，提示它们参与宿主对病原体的防御。在这项研究中，我们研究了CD1d在抵抗莱姆病螺旋体感染中的作用，伯氏疏螺旋体（Bb）是一种具有促炎脂质Ag的生物体，CD1d缺陷（CD1d(-/-)）小鼠菌株的Ph感染通常对这种病原体具有抵抗力，导致关节炎。病理与螺旋体DNA在组织中的流行率增加和bb特异性IgG的产生增加相关，包括体内螺旋体上快速下调的IgG。CD1d(-/-) Inice表现出高滴度的bb特异性IgG2a，这是一种常见于疾病易感小鼠而非抗病对照小鼠的同型。这些结果表明，CD1d缺乏损害宿主对螺旋体病原体的抵抗力，并且是赋予ph抗性小鼠具有易感小鼠品系的Ab和疾病特征的突变的第一个例子。
CD1 molecules can present microbial lipid Ag to T cells, suggesting that they participate in host defense against pathogens. hi this study, we examined the role of CD1d in resistance to infection with the Lyme disease spirochete, Borrelia burgdorferi (Bb), an organism with proinflammatory lipid Ag, Ph infection of CD1d-deficient (CD1d(-/-)) mouse strains normally resistant to this pathogen resulted in arthritis. Pathology correlated with an increased prevalence of spirochete DNA in tissues and enhanced production of Bb-specific IgG, including IgG to I-ig rapidly down-modulated on spirochetes in vivo. CD1d(-/-) Inice exhibited high-titer Bb-specific IgG2a, an isotype commonly induced in disease-susceptible mice but not in the disease-resistant control mice in this study. These results show that CD1d deficiency impairs host resistance to a spirochete pathogen, and are the first example of a mutation that imparts Ph-resistant mice with the Ab and disease profile of a susceptible mouse strain.