Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants.
Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants.
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DOI：
10.5468/ogs.2013.56.1.22
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发表时间：
2013-01
影响因子：
--
通讯作者：
Kim YJ
中科院分区：
文献类型：
--
作者：
Yang GY;Lee KA;Park MH;Park HS;Ha EH;Chun SH;Kim YJ
本研究的目的是确定对照组、先兆子痫（PE）孕妇和小于胎龄儿（SGA）婴儿尿nephrin的差异。我们还确定了母亲尿中nephrin的浓度是否与PE和SGA婴儿的后续发展相关。我们分析了正常对照组（n=50）、SGA婴儿（n=40）和PE孕妇（n=33）在妊娠早期、中期和晚期的孕妇尿nephrin水平。尿nephrin浓度测定nephrin酶联免疫吸附测定试剂盒。校正血肌酐后，先兆子痫组和SGA组尿nephrin水平均高于对照组（P<0.05）。妊娠晚期合并SGA和PE的孕妇尿nephrin浓度较高（P<0.05），妊娠早期合并SGA的孕妇尿nephrin浓度较高（P<0.05）。nephrin预测正常妊娠SGA的敏感性和特异性在孕早期分别为67%和89%，孕中期分别为60%和79%，孕晚期分别为80%和84%。nephrin预测正常妊娠PE的敏感性和特异性在孕早期分别为67%和83%，孕晚期分别为73%和79%。我们认为，尿nephrin可作为妊娠期PE和SGA婴儿风险的早期标志物。
The objective of this study was to determine the differences in urinary nephrin among controls, gravidas with preeclampsia (PE), and small-for-gestational age (SGA) infants. We also determined whether or not maternal urinary concentrations of nephrin are associated with the subsequent development of PE and SGA infants. We analyzed maternal urinary levels of nephrin in women who were normal controls (n=50), women who were delivered SGA infants (n=40), and gravidas with PE (n=33) in the first, second and third trimesters. Urinary nephrin concentrations were measured with nephrin enzyme-linked immunosorbent assay kits. The levels of urinary nephrin were higher in gravida developing preeclampsia or SGA than in controls after adjusting serum creatinine (P<0.05 for both). Maternal urine concentrations of nephrin were higher in pregnancies complicated by SGA and PE in the third trimester (P<0.05), and also higher in pregnancies complicated by SGA in the first trimester (P<0.05). The sensitivity and specificity of nephrin in predicting SGA from normal pregnancies were 67% and 89% in the first trimester, 60% and 79% in the second trimester, and 80% and 84% in the third trimester, respectively. The sensitivity and specificity of nephrin in predicting PE from normal pregnancies were 67% and 83% in the first trimester and 73% and 79% in the third trimester, respectively. We suggest that urinary nephrin can be used as an early marker in pregnancies at risk for developing PE and SGA infants.