Clinical characteristics in early Parkinson's disease in a Central California population-based study
Clinical characteristics in early Parkinson's disease in a Central California population-based study
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DOI：
10.1002/mds.20513
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发表时间：
2005-09-01
影响因子：
8.6
通讯作者：
Ritz, B
中科院分区：
文献类型：
--
作者：
Kang, GA;Bronstein, JM;Ritz, B
特发性帕金森病（PD）个体的表型外观存在相当大的差异，除了潜在的疾病病因外，这可能会转化为疾病进展的差异。在这篇文章中，我们报告了1998年1月至2003年6月期间居住在加州中部主要农村社区的162例诊断为临床可能PD的患者的人口统计学和临床特征。大多数受试者为白人，男性，年龄在60 - 79岁之间。运动僵硬型和震颤显性型较混合型多见。大多数受试者表现出僵硬（92.0%）、运动迟缓（95.7%）的运动体征。和步态问题（87.0%），而不到一半（43.3%）的受试者表现出震颤。四分之三的患者接受Hoehn和Yahr量表评分为2级或更高。三分之一的患者接受左旋多巴治疗，60岁以下的患者更可能接受多巴胺激动剂治疗。在首次诊断后的3年内，13%的受试者表现出一些抑郁症的迹象，17%的受试者符合轻度痴呆的标准。在我们的研究对象中，17.3%的一级或二级亲属有帕金森病家族史，15.4%的家族史有原发性震颤，14.2%的家族史有阿尔茨海默病。本研究代表了以人群为基础的方式招募的处于PD初始阶段的美国农村居民的最广泛的表型描述;未来的随访可能提供有关这些症状/体征的预后指示的有价值的信息，并提高我们对PD潜在病因的理解。(C)2005年，任上海市人民政府副市长。
There is considerable variation in the phenotypic appearance of individuals with idiopathic Parkinson's disease (PD), which may translate into differences in disease progression in addition to underlying disease etiology. In this publication, we report on the demographic and clinical characteristics of 162 individuals diagnosed with clinically probable PD from January 1998 to June 2003 who resided in predominantly rural communities in central California. The majority of the subjects were Caucasian, male, and between 60 and 79 years of age. The akinetic-rigid and tremor-dominant subtypes were more common than the mixed subtype. The majority of subjects displayed motor signs of rigidity (92.0%), bradykinesia (95.7%). and gait problems (87.0%), whereas less than half (43.3%) of the subjects displayed a tremor. Three fourths of patients received a Hoehn and Yahr Scale score of Stage 2 or higher. One third of the patients were treated with levodopa, and patients under 60 years of age were more likely to be treated with dopamine agonists. Within 3 years after first diagnosis, 13% of subjects showed some signs of depression and 17% of subjects met criteria for mild dementia. Among our subjects, 17.3% reported a family history of PD in first- or second-degree relatives,15.4% a family history of essential tremor, and 14.2% of Alzheimer's disease. This study represents the most extensive phenotypic description of rural U.S. residents in the initial stages of PD who were recruited in a population-based manner; future follow-up may provide valuable information regarding the prognostic indication of these symptoins/signs and improve our understanding of the underlying etiology of PD. (C) 2005 Movement Disorder Society.