Urethral Injection Therapy: What is the Mechanism of Action?
Urethral Injection Therapy: What is the Mechanism of Action?
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DOI：
10.1002/nau.20602
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发表时间：
2008-01-01
影响因子：
2
通讯作者：
Lose, Gunnar
中科院分区：
文献类型：
--
作者：
Klarskov, Niels;Lose, Gunnar
目的：注射治疗的作用机制几乎是未知的。尿道压力反射法（UPR）是一种测量尿道压力和尿道横截面积的新技术。UPR提供了可靠的生理意义参数，用于研究尿道注射治疗的机制。材料与方法：对15例应激性尿失禁（9例女性）和混合性尿失禁（6例女性）患者在尿道注射治疗前和治疗后101天进行UPR分析。患者主观判断其压力和冲动症状是否治愈/改善，几乎没有变化或恶化。结果：10例患者经注射治疗后痊愈/好转。没有人变得更糟。6例患者在注射前出现急迫症状，注射后无明显改变。根据患者对疗效的主观评价将患者分为两组。1组有效（10名女性），1组无效（5名女性）。治疗后患者挤压口压力明显升高。其他参数不变。平均挤压开口压力显著增加(P
Aims: The mechanism of action of injection therapy is Virtually unknown. Urethral Pressure Reflectometry (UPR) is a novel technique for measuring pressure and cross-sectional area in the urethra. UPR which provides reliable physiological meaningful parameters was used to study the mechanism of urethral injection therapy. Materials and Methods: Fifteen patients with stress urinary, incontinence (nine women) and mixed incontinence (six women) were investigated with UPR before and 101 days after urethral injection therapy. The patients subjectively judged if their stress and urge symptoms were cured/improved Almost Unchanged or worsened. Results: Ten women were cured/improved after the injection therapy. None became worse. Six patients had urge symptoms before injection therapy which did not change after the procedure. The patients were divided into two groups based on their subjective assessments of effect. One group with effect (10 women) and 1 group without effect (5 women). The patients had significantly higher squeezing opening pressure after the treatment. The other parameters were unchanged. The mean squeezing opening pressure increased significantly (P