Endometrial compaction does not predict live birth rate in single euploid frozen embryo transfer cycles
Endometrial compaction does not predict live birth rate in single euploid frozen embryo transfer cycles
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DOI：
10.1007/s10815-020-02043-7
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发表时间：
2021-01-03
影响因子：
3.1
通讯作者：
Kroener, Lindsay
中科院分区：
文献类型：
--
作者：
Riestenberg, Carrie;Quinn, Molly;Kroener, Lindsay
目的评价序贯经阴道超声子宫内膜致密化与药物治疗单次整倍体冷冻胚胎移植(FET)周期活产率的关系。方法在一家私立生育诊所进行前瞻性观察队列研究。对2018年1月至12月期间接受FETS的患者进行了纳入评估。通过连续经阴道超声测量雌激素期末和胚胎移植前一天之间子宫内膜厚度的变化，用来划分压缩(>；=5%)、无变化或扩张(>；=5%)周期。然后比较不同组间的FET周期结果。主要结果是活产。次要结局包括临床妊娠率和自然流产率。结果在259个单整倍体药物FET中，仅43/259个周期(16.6%)表现为<gt；=5%紧缩性，152/259个周期(58.7%)扩张，而/259个周期无变化(24.7%)。压缩周期(58.1%)、无变化周期(54.7%)和扩张周期(58.6%)之间的活产率没有差异，p=0.96。两组间的临床妊娠率和自然流产率也相似。结论绝大多数周期未见子宫内膜致密化。在这个队列中，用药的单个整倍体FET中，子宫内膜致密化与活出生率或自然流产率无关。
Purpose To evaluate whether endometrial compaction using sequential transvaginal ultrasound is associated with improved live birth rates in medicated single euploid frozen embryo transfer (FET) cycles. Methods Prospective observational cohort study at a private fertility clinic. Patients who underwent FETs between January and December 2018 were assessed for inclusion. The change in endometrial thickness between the end of the estrogen phase and the day before embryo transfer, measured by sequential transvaginal ultrasound, was used to categorize cycles with compaction (>= 5%), no change, or expansion (>= 5%). FET cycle outcomes were then compared between groups. The primary outcome was live birth. Secondary outcomes include clinical pregnancy rate and rate of spontaneous abortion. Results Of the 259 single euploid medicated FETs performed during the study period, only 43/259 (16.6%) of the cycles demonstrated >= 5% compaction, whereas 152/259 (58.7%) expanded and 64/259 (24.7%) were unchanged. Live birth rates did not differ between cycles with compaction (58.1%), no change (54.7%), or expansion (58.6%), p = 0.96. Clinical pregnancy and spontaneous abortion rates were also similar between groups. Conclusion The vast majority of cycles did not demonstrate endometrial compaction. Endometrial compaction is not associated with live birth rate or spontaneous abortion rate in medicated single euploid FETs in this cohort.