Sudden Hypoacusis Treated with Hyperbaric Oxygen Therapy: A Controlled Study
Sudden Hypoacusis Treated with Hyperbaric Oxygen Therapy: A Controlled Study
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高压氧疗法治疗突发听力减退：一项对照研究
DOI：
10.1177/014556130108000911
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
G. De Iaco
中科院分区：
文献类型：
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作者：
B. Fattori;S. Berrettini;A. Casani;A. Nacci;A. De Vito;G. De Iaco
术语突发性听觉减退描述的是一种起因不明的快速发病的听力损失，可发展为严重耳聋。在治疗突发性耳聋的许多治疗方案中，高压氧治疗（HOT）起着主导作用。我们研究了50例在突发听觉减退48小时内被转介到我们耳鼻喉科的患者。我们随机分配其中30名患者接受每日一次的HOT治疗，持续10天；其余20例患者接受静脉血管扩张剂治疗10天。通过计算频率在500至4000 Hz之间的平均听力阈值，以及评估基线和停止治疗后10天记录的阈值调性听力学结果，评估所有患者对治疗的反应。这些结果，加上其他听力学和耳神经学检查的结果显示，无论年龄和性别变量如何，HOT组患者对治疗的反应明显大于血管扩张剂组患者。HOT组中明显更多的患者出现了良好或显著的反应。在两组中，神经性听觉减退患者的反应明显好于病情较轻的患者。根据我们的研究结果，再加上氧疗耐受性良好且无副作用，我们得出结论，HOT应被视为突发性耳聋患者的首选治疗方法。
The term sudden hypoacusis describes a hearing loss of rapid onset and unknown origin that can progress to severe deafness. Of the many therapeutic protocols that have been proposed for treating sudden hypoacusis, hyperbaric oxygen therapy (HOT) plays a leading role. We studied 50 patients who had been referred to our ENT unit within 48 hours of the onset of sudden hypoacusis. We randomly assigned 30 of these patients to undergo once-daily administration of HOT for 10 days; the other 20 patients were treated for 10 days with an intravenous vasodilator. Response to therapy in all patients was evaluated by calculating the mean hearing threshold at frequencies between 500 and 4, 000 Hz and by assessing liminal tonal audiometry results recorded at baseline and 10 days after the cessation of treatment. These results, plus the findings of other audiologic and otoneurologic examinations, revealed that the patients in the HOT group experienced a significantly greater response to treatment than did those in the vasodilator group, regardless of age and sex variables. Significantly more patients in the HOT group experienced a good or significant response. In both groups, patients with pantonal hypoacusis responded significantly better than did those with a milder condition. Based on our findings, coupled with the fact that oxygen therapy is well tolerated and produces no side effects, we conclude that HOT should be considered the preferred treatment for patients with sudden hypoacusis.