Hippocampal Subregions are Differentially Affected in the Progression to Alzheimer's Disease
Hippocampal Subregions are Differentially Affected in the Progression to Alzheimer's Disease
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DOI：
10.1002/ar.21493
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发表时间：
2012-01-01
影响因子：
2
通讯作者：
Killiany, Ronald J.
中科院分区：
文献类型：
--
作者：
Greene, Sarah J.;Killiany, Ronald J.
磁共振成像(MRI)测量的海马区萎缩(HP)是阿尔茨海默病(AD)进展的一个有前途的生物标志物。Hp沿纵轴的亚区被发现具有独特的功能，并且在进展为AD的过程中经历了不同的变化。这些HP亚区与其他潜在生物标志物之间的关系知之甚少，例如神经心理(NP)、遗传和脑脊液(CSF)β淀粉样蛋白和tau指标。这项研究的目的是细分海马体，以确定在正常对照组、轻度认知障碍和AD受试者中，头部、身体和尾部是如何受到影响的，并调查与Hp亚区和其他潜在生物标志物的关系。对120名阿尔茨海默病神经成像计划参与者的MRI扫描使用Freesurfer进行处理，并使用3D Slicer对HP进行细分。每个亚区在不同组之间进行比较，并使用相关性来确定与NP、遗传和脑脊液测量的关系。结果表明，在AD中，HP亚区正在经历差异性萎缩，并与NP和CSF数据显示出独特的关系。判别函数分析显示，当结合NP和CSF措施时，这些区域能够按诊断组进行分类，并对12个月内将会和不会进展为AD的MCI患者进行分类。Anat Rec，2012年。(C)2011年威利期刊公司。
Atrophy within the hippocampus (HP) as measured by magnetic resonance imaging (MRI) is a promising biomarker for the progression to Alzheimer's disease (AD). Subregions of the HP along the longitudinal axis have been found to demonstrate unique function, as well as undergo differential changes in the progression to AD. Little is known of relationships between such HP subregions and other potential biomarkers, such as neuropsychological (NP), genetic, and cerebral spinal fluid (CSF) beta amyloid and tau measures. The purpose of this study was to subdivide the hippocampus to determine how the head, body, and tail were affected in normal control, mild cognitively impaired, and AD subjects, and investigate relationships with HP subregions and other potential biomarkers. MRI scans of 120 participants of the Alzheimer's Disease Neuroimaging Initiative were processed using FreeSurfer, and the HP was subdivided using 3D Slicer. Each subregion was compared among groups, and correlations were used to determine relationships with NP, genetic, and CSF measures. Results suggest that HP subregions are undergoing differential atrophy in AD, and demonstrate unique relationships with NP and CSF data. Discriminant function analyses revealed that these regions, when combined with NP and CSF measures, were able to classify by diagnostic group, and classify MCI subjects who would and would not progress to AD within 12 months. Anat Rec, 2012. (C) 2011 Wiley Periodicals, Inc.