Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
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DOI：
10.1016/j.ejps.2019.104967
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发表时间：
2019-09-01
影响因子：
4.6
通讯作者：
Jannin, Vincent
中科院分区：
文献类型：
--
作者：
Boyd, Ben J.;Bergstrom, Christel A. S.;Jannin, Vincent
水溶性差的药物仍然是治疗多种疾病的一类有问题但重要的药物化合物。它们的发现率仍然很高，而且它们的发展通常受到我们对给药和吸收之间发生的复杂化学、生理和生化过程如何单独和共同影响生物利用度缺乏完整了解的限制。这篇综述定义了这些药物所面临的挑战，概述了解决这一挑战的当代策略，以及随后对难溶性药物的输送技术进行的计算机和体外评估。提出了后续步骤和未满足的需求，为该领域的未来研究提供了路线图，以考虑在难溶于水的化合物的输送方面取得进展。
Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a complete understanding of how the complex chemical, physiological and biochemical processes that occur between administration and absorption individually and together impact on bioavailability. This review defines the challenge presented by these drugs, outlines contemporary strategies to solve this challenge, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs. The next steps and unmet needs are proposed to present a roadmap for future studies for the field to consider enabling progress in delivery of poorly water-soluble compounds.