Engrafted VHL peptide-delivered bone marrow stromal cells promote spinal cord repair in rats
Engrafted VHL peptide-delivered bone marrow stromal cells promote spinal cord repair in rats
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DOI：
10.1097/wnr.0b013e328336ee9a
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发表时间：
2010-03-10
期刊：
影响因子：
1.7
通讯作者：
Saito, Tomoyuki
中科院分区：
文献类型：
--
作者：
Yamazaki, Yoshiyuki;Kanno, Hiroshi;Saito, Tomoyuki
使用骨髓基质细胞（MSC）的干细胞疗法有望成为神经元再生的一种有前景的疗法。对于修复受损脊髓，移植前MSCs向神经元分化有较满意的效果。最近，通过细胞内递送 pVHL 衍生的合成肽（VHL 肽）已显示神经祖细胞/干细胞的神经元分化。在这里，我们表明，VHL 肽递送的 MSC 分化为神经元样细胞，并且移植的 VHL 肽递送的 MSC 比未递送的 MSC 更能恢复大鼠的行为。我们的结果表明，使用 VHL 肽递送的 MSC 将是修复受损脊髓的一种有前途的治疗策略。 NeuroReport 21:287-292 (C) 2010 Wolters Kluwer Health 垂直条 Lippincott Williams & Wilkins。
Stem cell-based therapy using bone marrow stromal cells (MSCs) has been expected to be a promising therapy for neuronal regeneration. To repair the injured spinal cord, neuronal differentiation of MSCs before transplantation has a more satisfactory effect. Recently, neuronal differentiation of neural progenitor/stem cells by an intracellular delivery of a pVHL-derived synthetic peptide (VHL peptide) has been shown. Here, we show that VHL peptide-delivered MSCs differentiated into neuron-like cells, and that engrafted VHL peptide-delivered MSCs more recovered the behaviors of the rats than that of nondelivered MSCs. Our result suggests that the use of VHL peptide-delivered MSCs would be a promising therapeutic strategy for repairing the injured spinal cord. NeuroReport 21:287-292 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.