Endogenous neurotensin is involved in estrous cycle related alterations in prepulse inhibition of the acoustic startle reflex in female rats
Endogenous neurotensin is involved in estrous cycle related alterations in prepulse inhibition of the acoustic startle reflex in female rats
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DOI：
10.1016/j.psyneuen.2007.11.005
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发表时间：
2008-02-01
影响因子：
3.7
通讯作者：
Nemeroff, Charles B.
中科院分区：
文献类型：
--
作者：
Kinkead, Becky;Yan, Feng;Nemeroff, Charles B.
卵巢激素调节声惊厥反射的脉冲前抑制(PPI)。在完整雌性啮齿动物身上研究PPI的性别、发情周期和卵巢激素调节的结果是不一致的。在实验1中，我们研究了雌性大鼠的PPI是否受一天的测试时间和发情周期阶段的影响。测定发情前期(P)和发情间期1天(D1)雌性大鼠的PPI，并与配偶进行比较。配偶和P雌性PPI显著高于D_1雌性。配偶和女性的PPI受一天的测试时间的影响显着，下午和晚上的PPI比早上要低。P女性的PPI不受一天测试时间的显著影响。以前的研究表明，中枢神经系统神经降压素(NT)神经元的动情周期调节，外周给药的NT受体激动剂调节PPI的方式类似于抗精神病药物。本研究的实验2旨在探讨内源NT是否参与PPI的发情周期调控。NT受体拮抗剂SR 142948A降低了D1和R期间高水平的PPI，相反，当在D1女性PPI低的一天时间进行测试时，给予典型的抗精神病药物氟哌啶醇和NT受体拮抗剂都显著增加了PPI。这些数据支持一天中的时间和发情周期阶段对雌性大鼠PPI的影响。PPI的发情周期变化在一定程度上是由内源NT介导的。(C)2007爱思唯尔有限公司。保留所有权利。
Ovarian hormones regulate prepulse inhibition (PPI) of the acoustic startle reflex. Results from studies in intact female rodents investigating sex, estrous cycle and ovarian hormone regulation of PPI are inconsistent. In experiment #1, we investigated whether PPI in female rats is influenced by the time of day of testing and the estrous cycle stage of the rat. PPI was examined across the day of proestrus (P) and diestrus 1 (D1) in females rats and compared to mates. PPI in mates and P female was significantly higher than in D1 females. PPI in mates and D1 females was significantly affected by the time of day of testing with PPI being reduced in the afternoon and evening compared to morning. PPI in P females was not significantly affected by the time of day of testing. Previous studies have demonstrated estrous cycle regulation of central nervous system neurotensin (NT) neurons and peripherally administered NT receptor agonists regulate PPI in a manner similar to antipsychotic drugs. Experiment #2 of this study was designed to examine whether endogenous NT is involved in estrous cycle regulation of PPI. The NT receptor antagonist SR 142948A reduced the high levels of PPI during D1 and R In contrast, when tested at a time of day in which PPI was low in D1 females, administration of both the typical antipsychotic drug haloperidol and the NT receptor antagonist significantly increased PPI. These data support an effect of time of day and estrous cycle stage on PPI in female rats. The estrous cycle variations in PPI are mediated in part by endogenous NT. (c) 2007 Elsevier Ltd. All rights reserved.