Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results
Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results
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DOI：
10.1038/ijo.2014.52
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发表时间：
2014-12-01
影响因子：
4.9
通讯作者：
van Baak, M. A.
中科院分区：
文献类型：
--
作者：
Aller, E. E. J. G.;Larsen, T. M.;van Baak, M. A.
背景技术背景：高膳食蛋白质（P）含量和低血糖指数（LGI）已被认为是有益的体重management.Objective：DIOGENES随机临床试验研究的影响，P和GI在超重或肥胖的成年人在欧洲的8个中心的减肥维护，但长期的研究是稀缺的。这项研究报告的1年结果，在两个中心，延长到1 year.METHOD：经过8周的低热量饮食（LCD），256名成年人（体重指数>27公斤米（-2））被随机分配到五个自由饮食12个月：高P/LGI（HP/LGI），HP/高GI（HP/HGI），低P/LGI（LP/LGI），LP/HGI和控制饮食。在前6个月，通过商店系统免费提供食物，在整个12个月期间，受试者接受营养师的指导。主要结果变量是在12个月的干预periods.Results的体重变化：在LCD期间，受试者失去了11.2（10.8，12.0）公斤（平均值（95%置信区间（CI）。12个月干预期间的平均体重恢复为3.9（95% CI 3.0-4.8）kg。HP饮食的受试者体重恢复低于LP饮食的受试者。1年后体重恢复的差异为2.0（0.4，3.6）kg（P = 0.017）（完成者分析，N = 139）或2.8（1.4，4.1）kg（P < 0.001）（意向治疗分析，N = 256）。GI对体重恢复没有一致的影响被发现。有没有临床相关的差异，在心脏代谢危险因素之间的饮食groups.CONCLUSION：一个更高的蛋白质含量的随意饮食改善体重减轻维持超重和肥胖的成年人超过12个月。
BACKGROUND: A high dietary protein (P) content and low glycemic index (LGI) have been suggested to be beneficial for weight management, but long-term studies are scarce.OBJECTIVE: The DIOGENES randomized clinical trial investigated the effect of P and GI on weight loss maintenance in overweight or obese adults in eight centers across Europe. This study reports the 1-year results in two of the centers that extended the intervention to 1 year.METHOD: After an 8-week low-calorie diet (LCD), 256 adults (body mass index >27 kg m(-2)) were randomized to five ad libitum diets for 12 months: high P/LGI (HP/LGI), HP/high GI (HP/HGI), low P/LGI (LP/LGI), LP/HGI and a control diet. During the first 6 months, foods were provided for free through a shop system and during the whole 12-month period, subjects received guidance by a dietician. Primary outcome variable was the change in body weight over the 12-month intervention period.RESULTS: During the LCD period, subjects lost 11.2 (10.8, 12.0) kg (mean (95% confidence interval (CI))). Average weight regain over the 12-month intervention period was 3.9 (95% CI 3.0-4.8) kg. Subjects on the HP diets regained less weight than subjects on the LP diets. The difference in weight regain after 1 year was 2.0 (0.4, 3.6) kg (P = 0.017) (completers analysis, N = 139) or 2.8 (1.4, 4.1) kg (P < 0.001) (intention-to-treat analysis, N = 256). No consistent effect of GI on weight regain was found. There were no clinically relevant differences in changes in cardiometabolic risk factors among diet groups.CONCLUSION: A higher protein content of an ad libitum diet improves weight loss maintenance in overweight and obese adults over 12 months.