Sex differences in spinal osteoarthritis in humans and rhesus monkeys (Macaca mulatta).
Sex differences in spinal osteoarthritis in humans and rhesus monkeys (Macaca mulatta).
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DOI：
10.1097/brs.0b013e31823ab7fc
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发表时间：
2012-05-15
期刊：
影响因子：
3
通讯作者：
Kramer PA
中科院分区：
文献类型：
--
作者：
Duncan AE;Colman RJ;Kramer PA
在人类和非人灵长类动物中对男性和女性脊柱骨关节炎进行的回顾性研究，以侧位脊柱胸腰椎X线片为特征，旨在描述男性和女性之间、雄性和雌性猕猴之间以及两种遗传学相关属之间脊柱骨关节炎的患病率和椎体分布差异。自然发生的脊柱骨关节炎在人类和恒河猴中表现相似。其他类型的骨关节炎，特别是膝关节和髋关节的骨关节炎，揭示了人类的性别差异。关于脊柱骨关节炎，已经注意到性别差异，但没有一致的结果。猕猴的性别差异还没有被研究过。采用寰椎评分法评估椎间隙狭窄和骨赘的影像学证据。根据性别、年龄、体重（仅猕猴）和脊柱位置（人T4-L5;猕猴T8-L7）确定患病率。猕猴的平均得分在性别之间存在差异，但在男性和女性之间没有差异。沿着脊柱受累的模式在雄性和雌性猴子中是相同的，但在男性和女性之间是不同的：女性有更多的胸椎受累，男性有更多的腰椎受累。总体而言，猴子的骨关节炎患病率明显高于人类。骨关节炎患病率的性别差异很可能是体重影响的替代指标。猴子的性别差异很明显，因为雄性比雌性重得多。在人类中，患病率没有明显的性别差异，男性和女性的体重有很大的重叠。当仅检查平均评分时，男性和女性之间骨关节炎累及沿着脊柱的位置差异被掩盖。
Retrospective study of male and female spinal osteoarthritis, characterized by lateral spine thoracolumbar radiographs, in humans and nonhuman primates To characterize differences in prevalence and vertebral distribution of spinal osteoarthritis between men and women, between male and female macaques, and between the two phylogenetically related genera. Naturally occurring spinal osteoarthritis manifests similarly in humans and rhesus macaques. Other types of osteoarthritis particularly of the knee and hip have revealed gender differences in humans. In regard to spinal osteoarthritis, gender differences have been noted but without consistent results. Sex differences in macaques have not been examined. Radiographic evidence of disc space narrowing and osteophytosis was assessed using an atlas scoring method. Prevalence was determined according to sex, age, body mass (for macaques only) and spinal location (human T4-L5; macaque T8-L7). Average scores in macaques differed between the sexes, but they did not differ between men and women. The pattern of involvement along the spine was the same in male and female monkeys but differed between men and women: women had more thoracic involvement and men had more lumbar involvement. Overall, monkeys had a significantly higher prevalence of osteoarthritis than humans. The appearance of sex differences in the prevalence of osteoarthritis is most likely a proxy measure for the affect of body mass. Sex differences were apparent in monkeys due to the fact that males are significantly heavier than females. No gender difference in prevalence was apparent in humans and there is substantial overlap in body mass between men and women. Differences in the location of osteoarthritic involvement along the spine between men and women were obscured when only average scores were examined.