Global and regional dissemination and evolution of Burkholderia pseudomallei.
Global and regional dissemination and evolution of Burkholderia pseudomallei.
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DOI：
10.1038/nmicrobiol.2016.263
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发表时间：
2017-01-23
影响因子：
28.3
通讯作者：
Peacock SJ
中科院分区：
文献类型：
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作者：
Chewapreecha C;Holden MT;Vehkala M;Välimäki N;Yang Z;Harris SR;Mather AE;Tuanyok A;De Smet B;Le Hello S;Bizet C;Mayo M;Wuthiekanun V;Limmathurotsakul D;Phetsouvanh R;Spratt BG;Corander J;Keim P;Dougan G;Dance DA;Currie BJ;Parkhill J;Peacock SJ
环境细菌假鼻疽伯克霍尔德氏菌每年在全球范围内导致约165,000例人类类鼻疽病，也被归类为生物治疗剂。我们使用了79年来收集的来自30个国家的469株假鼻疽杆菌的全基因组序列来探索它的地理传播。我们的数据表明，澳大利亚是一个早期的储藏者，传播到东南亚，然后再传播到南亚和东亚。在马来半岛内部，以及湄公河沿岸的国家之间，都多次观察到重新引入。我们的数据支持中美洲和南美洲分离株起源于非洲，在1650年至1850年之间将假鼻疽引入美洲，提供了与奴隶贸易的时间联系。我们还仅在澳大拉西亚或东南亚分离株中确定了地理上不同的基因/变异，与毒力相关的基因在那些被过度表达的基因中。这为受地理限制的类鼻疽病的临床表现提供了一个潜在的解释。
The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide, and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia, and East Asia. Repeated reintroduction was observed within the Malay Peninsula, and between countries bordered by the Mekong river. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those overrepresented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.