QUANTITATIVE-EVALUATION OF REGIONAL DIFFERENCES BETWEEN EPITHELIA IN THE ADULT-MOUSE
QUANTITATIVE-EVALUATION OF REGIONAL DIFFERENCES BETWEEN EPITHELIA IN THE ADULT-MOUSE
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DOI：
10.1016/0003-9969(81)90118-7
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发表时间：
1981-01-01
影响因子：
3
通讯作者：
MACKENZIE, IC
中科院分区：
文献类型：
--
作者：
HILL, MW;BERG, JH;MACKENZIE, IC
观察了成年小鼠耳、尾、足部皮肤和上颚、颊、舌部口腔黏膜的组成和增殖情况。皮肤有核细胞层厚度变化约2倍；在口腔粘膜中也发现了类似的范围，但口腔粘膜比皮肤厚得多。上皮细胞厚度与有核细胞数量无直接关系。在给予硫酸长春碱和上皮周转率后，对增殖活性进行了评估，结果显示口腔上皮的增殖活性范围广泛，但比表皮的增殖速度更快，这表明功能应激与增殖活性之间存在关系。所使用的标准清楚地区分了形态学上不同的上皮，并应证明在检查上皮组织分化实验产生的变化是有用的。
The composition and proliferation of skin from the ear, tail and footpad and oral mucosa from the palate, cheek and tongue of adult mice were examined. The thickness of the nucleated cell layer of skin showed an approximately 2-fold variation; a similar range was found between that of oral mucosae but that was considerably thicker than skin. No direct correlation between epithelial thickness and the number of nucleated cells was observed. Proliferative activity, assessed following the administration of vinblastine sulfate and turnover of the epithelium showed a broad range of activities but more rapid in the oral epithelia than in the epidermis, suggesting a relationship between functional stress and proliferative activity. The criteria used clearly distinguish between morphologically different epithelia and should prove useful in examining experimentally produced changes in epithelial histodifferentiation.