NOCICEPTIVE RESPONSES OF NEURONS IN MEDIAL THALAMUS AND THEIR RELATIONSHIP TO SPINOTHALAMIC PATHWAYS
NOCICEPTIVE RESPONSES OF NEURONS IN MEDIAL THALAMUS AND THEIR RELATIONSHIP TO SPINOTHALAMIC PATHWAYS
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DOI：
10.1152/jn.1978.41.6.1592
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发表时间：
1978-01-01
影响因子：
2.5
通讯作者：
WAGMAN, IH
中科院分区：
文献类型：
--
作者：
DONG, WK;RYU, H;WAGMAN, IH
猫内侧丘脑的细胞外研究揭示了4种类型的体感神经元。主要分布在N。（nucleus）parafascicularis，n.束旁核和束旁核centralislateralis; n.正中中心在每个核内或核之间没有神经元的功能分离。每种类型的神经元都有大的，通常是双侧的感受区。在内侧丘脑内没有发现神经元的躯体组织。包括72%的样品（总共109个中的78个）的伤害性（N）和伤害性敲击（NT）神经元被认为是伤害性的。敲击（T）神经元（10%）只对施加在皮肤或下层组织上的轻快但无害的敲击做出反应。这些细胞仅由A-α-受体的激活驱动。和A-β-纤维受抑制的（I）神经元（18%）具有静息放电，其被伤害性刺激和A-δ刺激抑制。和C纤维组。从监测周围诱发反应的伤害性N和NT神经元的脊髓选择性病变前后的结果强烈建议，脊髓丘脑束是唯一的脊髓预测介导的A-和C-纤维输入到这些细胞。每一条脊髓丘脑束显然携带着来自身体两侧的信息。
An extracellular study of the cat medial thalamus revealed 4 types of somatosensory neurons. These were located primarily in the n. (nucleus) parafascicularis, n. subparafascicularis and n. centralis lateralis; none were found in the n. centrum medianum. There was no functional segregation of neurons within each nucleus or between nuclei. Each type of neuron had large and often bilateral receptive areas. No somatotopic organization of neurons was found within the medial thalamus. Noxious (N) and noxious-tap (NT) neurons comprising 72% of the sample (78 of 109 total) were considered to be nociceptive. Tap (T) neurons (10%) responded only to brisk but innocuous taps applied to skin or underlying tissue. These cells were driven only by activation of A-.alpha.- and A-.beta.-fibers. Inhibited (I) neurons (18%) had resting discharges that were inhibited by noxious stimuli and stimulation of A-.delta.- and C-fiber groups. The results obtained from monitoring the peripherally evoked responses of nociceptive N and NT neurons before and after selective lesions of the spinal cord strongly suggested that the spinothalamic tracts were the only spinal projections mediating A- and C-fiber input to these cells. Each spinothalamic tract apparently carried information originating from both sides of the body.