New lignans from the perisperm of Sesamum indicum
New lignans from the perisperm of Sesamum indicum
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DOI：
10.1021/jf061694j
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发表时间：
2006-10-04
影响因子：
6.1
通讯作者：
Skaltsounis, Alexios-Leandros
中科院分区：
文献类型：
--
作者：
Grougnet, Raphael;Magiatis, Prokopios;Skaltsounis, Alexios-Leandros
以XAD-4吸附树脂为吸附剂，对芝麻外种皮中的多酚类物质进行了富集。化学分析所获得的提取物导致16木脂素的鉴定。其中两个新的木脂素，（+）-saminol和（+）-episesaminone-9-O-beta-D-sophoroside已被分离。此外，（-）-芝麻乳酚的相对立体化学，以前报告为洋地黄内酯醇A差向异构体，已明确定义使用X射线晶体学。所有新化合物的结构都是通过光谱方法确定的，主要是通过1D和2D NMR技术（HMQC，HMBC和NOESY）和质谱的协同应用。
A procedure, based on XAD-4 adsorption resin, which permits the obtainment of enriched polyphenolic extracts from Sesamum indicum perisperm (coat) has been developed. Chemical analysis of the obtained extracts led to the identification of 16 lignans. Among them, two new lignans, (+)-saminol and (+)-episesaminone-9-O-beta-D-sophoroside, have been isolated. Additionally, the relative stereochemistry of (-)-sesamolactol, previously reported as todolactol A epimer, has been unequivocally defined using X-ray crystallography. The structures of all new compounds were determined by spectroscopic methods, mainly by the concerted application of 1D and 2D NMR techniques (HMQC, HMBC, and NOESY) and mass spectroscopy.