Human telomerase reverse transcriptase protein expression is associated with survival in patients with oral squamous cell carcinoma.
Human telomerase reverse transcriptase protein expression is associated with survival in patients with oral squamous cell carcinoma.
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发表时间：
2022
影响因子：
1.4
通讯作者：
Kazuya Haraguchi;M. Habu;N. Yada;M. Sasaguri;I. Yoshioka;K. Tominaga
中科院分区：
文献类型：
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作者：
Kazuya Haraguchi;M. Habu;N. Yada;M. Sasaguri;I. Yoshioka;K. Tominaga
尽管诊断和治疗有所改善，但口腔鳞状细胞癌（OSCC）的5年生存率仍然很低，平均为50%。端粒酶在85%的恶性肿瘤中表达，可能在人类癌变中起重要作用。它的催化成分是人类端粒酶逆转录酶（hTERT），人们一直认为，但尚未证实，它与OSCC的生存有关。我们通过评估hTERT蛋白与临床病理表现和OSCC生存的关系来研究hTERT蛋白是否是OSCC的预后因素。我们发现，与hTERT高表达的患者相比，hTERT低表达的患者生存时间明显更长，包括5年总生存期更长。此外，总生存率与hTERT表达、肿瘤的组织学分级和N状态有显著相关。无病生存与hTERT的表达、肿瘤的组织学分级和N状态以及侵袭方式有显著关系。这些结果提示hTERT蛋白参与了颈部淋巴结转移，其水平可能在癌变过程中升高，并可能影响肿瘤的侵袭。我们认为本研究首次证明高hTERT表达的OSCC比低hTERT表达的OSCC预后更差。
Despite improvements in diagnosis and treatment, the 5-year survival of oral squamous cell carcinoma (OSCC), no matter the location, remains low, averaging 50%. Telomerase is expressed in 85% of malignancies and may play an important role in human carcinogenesis. Its catalytic component is human telomerase reverse transcriptase (hTERT), which has been thought, but not proven, to be involved in survival with OSCC. We investigated whether hTERT protein was a prognostic factor in OSCC by evaluating its association with clinicopathologic findings and OSCC survival. We found that in comparison to patients with high hTERT expression, patients with low hTERT expression survived significantly longer, including a longer 5-year overall survival. In addition, overall survival was significantly correlated to hTERT expression and the histologic grade and N status of the tumor. Disease-free survival was significantly related to hTERT expression, the histologic grade and N status of the tumor, and mode of invasion. These results suggest that hTERT protein is involved in cervical lymph node metastasis, that its levels may be increased during carcinogenesis, and that it may influence tumor invasion. We believe that this study is the first to demonstrate that OSCC with high hTERT expression carries a worse prognosis than cases with low hTERT expression.