Lateral tension increases the line tension between two domains in a lipid bilayer membrane
Lateral tension increases the line tension between two domains in a lipid bilayer membrane
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DOI：
10.1103/physreve.75.011919
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Cohen, Fredric S.
中科院分区：
文献类型：
--
作者：
Akimov, Sergey A.;Kuzmin, Peter I.;Cohen, Fredric S.
计算了外加横向张力对脂双层膜中两个不同厚度区域之间的线张力的影响。厚域被视为液体有序相，以模拟生物膜中的筏;薄域被认为是液体无序相，以模拟周围区域。在我们的模型中，单层弹性扭曲的边界，以创建一个平滑的，而不是阶梯状的边界，以避免暴露的厚筏的疏水内部的水。这种变形的能量由展曲和倾斜的基本变形来描述。每单位边界长度的能量产生筏板的线张力。施加横向张力改变基本变形，使得线张力增加。当筏板的自发曲率大于围壁的自发曲率时，线张力的增加较大;如果筏板的自发曲率小于围壁的自发曲率，则由于施加横向张力而引起的线张力的增加较为适度。
The effect of an external applied lateral tension on the line tension between two domains of different thickness in a lipid bilayer membrane is calculated. The thick domain is treated as a liquid-ordered phase in order to model a raft in a biological membrane; the thin domain is considered a liquid-disordered phase to model the surrounding region. In our model, the monolayers elastically distort at the boundary to create a smooth rather than steplike boundary to avoid exposure of the hydrophobic interior of the thick raft to water. The energy of this distortion is described by the fundamental deformations of splay and tilt. This energy per unit length of boundary yields the line tension of the raft. Applying lateral tension alters the fundamental deformations such that line tension increases. This increase in line tension is larger when the spontaneous curvature of a raft is greater than that of the surround; if the spontaneous curvature of the raft is less than that of the surround, the increase of the line tension due to application of the lateral tension is more modest.