FNDC5/irisin - their role in the nervous system and as a mediator for beneficial effects of exercise on the brain.
FNDC5/irisin - their role in the nervous system and as a mediator for beneficial effects of exercise on the brain.
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DOI：
10.3233/bpl-150019
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Wrann CD
中科院分区：
文献类型：
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作者：
Wrann CD
运动可以改善认知功能，改善阿尔茨海默病等神经退行性疾病的预后。这种作用与脑源性神经营养因子(BDNF)的表达增加有关。然而，这种神经营养因子升高的潜在分子机制仍不清楚。最近，我们报道了PGC-1α-FNDC5/Irisin通路，该通路在小鼠的海马区被运动激活，并诱导包括脑源性神经营养因子在内的神经保护性基因程序。这篇综述将集中在FNDC5及其分泌型“虹膜蛋白”，一种新发现的肌肉因子，以及它们在神经系统中的作用及其治疗潜力。此外，我们还将简要讨论其他运动诱导的肌动蛋白在积极的大脑效应中的作用。
Exercise can improve cognitive function and the outcome of neurodegenerative diseases, like Alzheimer’s disease. This effect has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Recently, we have reported a PGC-1α-FNDC5/irisin pathway, which is activated by exercise in the hippocampus in mice and induces a neuroprotective gene program, including Bdnf. This review will focus on FNDC5 and its secreted form “irisin”, a newly discovered myokine, and their role in the nervous system and its therapeutic potential. In addition, we will briefly discuss the role of other exercise-induced myokines on positive brain effects.