SEX-DIFFERENCES IN THE RAPID AND ACUTE EFFECTS OF ESTROGEN ON STRIATAL D-2 DOPAMINE-RECEPTOR BINDING
SEX-DIFFERENCES IN THE RAPID AND ACUTE EFFECTS OF ESTROGEN ON STRIATAL D-2 DOPAMINE-RECEPTOR BINDING
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DOI：
10.1016/0006-8993(94)91229-7
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发表时间：
1994-02-21
期刊：
影响因子：
2.9
通讯作者：
BECKER, JB
中科院分区：
文献类型：
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作者：
BAZZETT, TJ;BECKER, JB
研究了去势（CAST）或去卵巢（OVX）大鼠在给予低剂量苯甲酸雌二醇（EB）、EB后黄体酮或对照物反复治疗后纹状体D-2多巴胺（DA）受体结合的局部变化。在两个单独的实验中，OVX大鼠尾侧纹状体D-2 DA受体结合明显减少，而CAST大鼠单次注射bf - EB后30分钟无明显变化。注射EB后4 h， CAST大鼠喙侧纹状体纹状体D-2 DA受体结合明显增加。在OVX或CAST大鼠中，EB加孕酮治疗均无效果。此外，CAST大鼠吻侧纹状体侧区D-2 DA受体结合明显低于OVX大鼠。这些结果表明，雌性激素对纹状体D-2 DA受体结合的性别二态性和区域特异性影响，以及在没有循环性腺激素的情况下纹状体D-2 DA受体结合的显著性别差异。目前的研究结果是根据以往报道性激素对纹状体DA介导行为影响的性别差异进行讨论的。
Regional changes in striatal D-2 dopamine (DA) receptor binding in castrated (CAST) or ovariectomized (OVX) rats were investigated following administration of a low dose of estradiol benzoate (EB), repeated treatment with EB followed by progesterone, or vehicle. In two separate experiments, there was a significant decrease in striatal D-2 DA receptor binding in caudal striatum from OVX, but not CAST rats 30 min after a single injection bf EB. In CAST rats, there was a significant increase in striatal D-2 DA receptor binding in rostral striatum 4 h after injection of EB. There was no effect of EB plus progesterone treatment in either OVX or CAST rats. In addition, CAST rats had significantly lower D-2 DA receptor binding in the lateral region of the rostral striatum than did OVX rats. These results show sexually dimorphic and regionally specific effects of estrogen on striatal D-2 DA receptor binding, and a significant sex difference in striatal D-2 DA receptor binding in the absence of circulating gonadal hormones. The present findings are discussed in light of previous reports of sex differences in gonadal hormone influences on striatal DA mediated behaviors.